A study to find the role of N acetyl cysteine given intraductally in the submandibular gland on reducing radiotherapy related side effects such as swallowing difficulties and voice changes in patients with oropharyngeal cancer undergoing radiotherapy.
Not Applicable
- Conditions
- Health Condition 1: C10- Malignant neoplasm of oropharynx
- Registration Number
- CTRI/2020/10/028521
- Lead Sponsor
- ENT Department
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Clinically, radiologically and biopsy proven cases of oropharyngeal cancer,
2.Planned for radical radiotherapy,
3.Patients giving written informed consent
Exclusion Criteria
1.Patient not giving consent,
2. <18 years, >70 years,
3.Decreased mouth opening (Trismus),
4.Having undergone a total laryngectomy,
5.History of radiotherapy in Head and Neck area
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in swallowing using Fibre-optic endoscopic evaluation of swallowing (FEES) and M.D. Anderson Dysphagia Inventory (MDADI) score. <br/ ><br> <br/ ><br>Changes in voice using Voice Handicap Index-10 (VHI-10) score. <br/ ><br>Timepoint: 0, 3 months
- Secondary Outcome Measures
Name Time Method Change in the salivary flow rate, pH and viscosity.Timepoint: 0, 3 months