MR-guided biopsy of liver metastases in patients with suspected pancreatic cancer
Completed
- Conditions
- Liver metastases10027476
- Registration Number
- NL-OMON47537
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
- Age older than 18 years.
- Patients with on CECT suspected pancreatic cancer and liver lesions detected by CE-DW-MRI.
- Liver lesions cannot be biopsied with transabdominal ultrasound.
- Written (signed and dated) informed consent.
Exclusion Criteria
- Successful ultrasound-guided liver biopsy with proven metastases.
- Insufficient command of the Dutch language to be able to understand the patient information
- Pregnancy
- Contraindication for MRI
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Feasibility of MR-guided liver biopsy</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Percentage representative histopathology of liver lesions.<br /><br>- Procedure duration<br /><br>- Procedure workflow<br /><br>- Occurrence of procedure related complications/adverse events<br /><br>- Lesion size<br /><br>- Skin-to-target length<br /><br>- Histopathologic analysis of metastases. Correlation between different aspects<br /><br>of lesions on MRI and HE-staining. Amount of fibrosis, tumor grade,<br /><br>angiogenesis (MVD).<br /><br>- Optimization of imaging protocol during liver biopsy procedure</p><br>