Effects of Casein Protein on Metabolism When Taken Prior to Sleep and in the Morning
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- resting metabolic rate
研究概览
简要总结
The purpose of this study is to investigate the effect of casein protein consumption both prior to sleep as well first thing in the morning on metabolism (increase satiety and appetite, lower resting metabolic rate, and lower blood sugar levels), when compared to nighttime protein or placebo consumption alone. Protein itself is a macronutrient that not only helps the body repair itself, and play a critical role in growth, it also aids in increasing satiety and decreasing appetite. Casein protein specifically is slow digesting dairy protein which may impact the body's metabolism for a longer period than other dairy proteins such as whey. The literature demonstrates nighttime protein ingestion prior to sleep increases metabolic rate and satiety the next morning. However, there appears to be no data on the metabolic effects of protein ingested both at night and in the morning.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
Blinded pre-made packets of protein or placebo with sample coding in a sealed envelope until the end of the study
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •aged 18-30
排除标准
- •lactose intolerant
- •having known sleep issues
- •being on a schedule that is not uniform week to week
- •those who do not eat animal-based diets
- •any known or suspected food allergies
- •any known health conditions (cardiovascular disease, IBS, high blood pressure, diabetes, crohn's disease)
- •those that have disordered eating
- •unwillingness to take blood sugar four times a day
- •being a female
研究组 & 干预措施
PRO pm, PRO am
Participants arrive to the lab, complete 30 mins resting metabolic rate assessment. Then they are provided with a shake to drink 30 mins before bed. They return to the lab the following morning for 30 min RMR, drink another shake and do 30 mins RMR before leaving the lab.
干预措施: protein or placebo (Dietary Supplement)
PRO pm, PLAC am
Participants arrive to the lab, complete 30 mins resting metabolic rate assessment. Then they are provided with a shake to drink 30 mins before bed. They return to the lab the following morning for 30 min RMR, drink another shake and do 30 mins RMR before leaving the lab.
干预措施: protein or placebo (Dietary Supplement)
PLAC pm, PRO am
Participants arrive to the lab, complete 30 mins resting metabolic rate assessment. Then they are provided with a shake to drink 30 mins before bed. They return to the lab the following morning for 30 min RMR, drink another shake and do 30 mins RMR before leaving the lab.
干预措施: protein or placebo (Dietary Supplement)
PLAC pm, PLAC pm
Participants arrive to the lab, complete 30 mins resting metabolic rate assessment. Then they are provided with a shake to drink 30 mins before bed. They return to the lab the following morning for 30 min RMR, drink another shake and do 30 mins RMR before leaving the lab.
干预措施: protein or placebo (Dietary Supplement)
结局指标
主要结局
resting metabolic rate
时间窗: baseline, during the intervention
indirect calorimetry to measure oxygen consumption (V02) and respiratory quotient (RQ)
blood glucose
时间窗: baseline, during the intervention
fasting and pre-meal blood glucose
次要结局
- dietary intake(during the intervention)
研究者
Angela Hillman
Assistant Professor
Ohio University