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临床试验/NCT06250270
NCT06250270进行中(未招募)早期 1 期

Effects of Casein Protein on Metabolism When Taken Prior to Sleep and in the Morning

Ohio University2 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2022年10月1日最近更新:
适应症

试验速览

阶段
早期 1 期
状态
进行中(未招募)
入组人数
15
试验地点
2
主要终点
resting metabolic rate

研究概览

简要总结

The purpose of this study is to investigate the effect of casein protein consumption both prior to sleep as well first thing in the morning on metabolism (increase satiety and appetite, lower resting metabolic rate, and lower blood sugar levels), when compared to nighttime protein or placebo consumption alone. Protein itself is a macronutrient that not only helps the body repair itself, and play a critical role in growth, it also aids in increasing satiety and decreasing appetite. Casein protein specifically is slow digesting dairy protein which may impact the body's metabolism for a longer period than other dairy proteins such as whey. The literature demonstrates nighttime protein ingestion prior to sleep increases metabolic rate and satiety the next morning. However, there appears to be no data on the metabolic effects of protein ingested both at night and in the morning.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Treatment
盲法
Double (Participant, Investigator)

盲法说明

Blinded pre-made packets of protein or placebo with sample coding in a sealed envelope until the end of the study

入排标准

年龄范围
18 Years 至 30 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • aged 18-30

排除标准

  • lactose intolerant
  • having known sleep issues
  • being on a schedule that is not uniform week to week
  • those who do not eat animal-based diets
  • any known or suspected food allergies
  • any known health conditions (cardiovascular disease, IBS, high blood pressure, diabetes, crohn's disease)
  • those that have disordered eating
  • unwillingness to take blood sugar four times a day
  • being a female

结局指标

主要结局

resting metabolic rate

时间窗: baseline, during the intervention

indirect calorimetry to measure oxygen consumption (V02) and respiratory quotient (RQ)

blood glucose

时间窗: baseline, during the intervention

fasting and pre-meal blood glucose

次要结局

  • dietary intake(during the intervention)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Angela Hillman

Assistant Professor

Ohio University

研究点 (2)

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