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临床试验/NCT02302378
NCT02302378已完成不适用

Hypotension in Spinal Anesthesia for Total Knee Joint Arthroplasty: a Comparison of Taylor's Approach With Paramedian Lumbar Approach

University of British Columbia2 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2015年1月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
30
试验地点
2
主要终点
Hypotension

研究概览

简要总结

Spinal anesthesia is a common technique for providing anesthesia for knee joint replacement surgery. The investigators wish to demonstrate that using a lower approach to spinal anesthetic (Taylor's approach of L5-S1) causes less low blood pressure while still providing adequate anesthesia for knee joint replacement surgery than a higher approach (L3-L4).

详细描述

  1. Purpose

To determine if Taylor's approach (paramedian, via L5-S1 interspace) to subarachnoid blockade produces less hypotension than the more commonly used paramedian lumbar approach (via L3-L4 interspace). 2. Hypothesis

Taylor's approach to subarachnoid blockade for total knee joint arthroplasty will result in less hypotension which requires treatment than a paramedian lumbar approach. 3. Justification

Taylor described a method of obtaining spinal anesthesia for urological procedures using a paramedian approach to L5-S1. This interspace is large and tends to be less affected by degenerative changes than the lumbar interspaces. Because of these attributes this approach can be used as an alternative to either midline or paramedian approaches to the lumbar vertebrae interspaces.

Hypotension is a frequent and important complication of spinal anesthesia. As the degree of hypotension correlates with the height of blockade achieved, performing the dural puncture at a lower interspace may result in less hypotension. Several previous studies have compared the degree of hypotension resulting from a subarachnoid block performed via different lumbar interspaces with conflicting results. However a direct comparison of the lower Taylor's approach with a lumbar approach has not been investigated previously.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Supportive Care
盲法
Single (Participant)

入排标准

年龄范围
20 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Able to understand study protocol and give informed consent
  • Presenting for primary total knee joint arthroplasty at University of British Columbia Hospital
  • American Society of Anesthesiology (ASA) Class 1, 2 or 3

排除标准

  • American Society of Anesthesiology (ASA) Class 4 or 45
  • Patients who have elected not to have spinal anesthesia for their procedure
  • Patients deemed clinically inappropriate for spinal anesthesia by the attending anesthesiologist
  • Patients who are allergic to Local Anesthetic or Ultrasound gel.

结局指标

主要结局

Hypotension

时间窗: For duration of total knee joint replacement, an expected average of 1 hour

Level of decrease in Blood Pressure following administration of spinal anesthetic

次要结局

  • Success of central neuraxial blockade(30 minutes)
  • Time taken for technique(For duration of spinal anesthetic procedure, an expected duration of 5 minutes)
  • Patient acceptability of technique(For duration of spinal anesthetic procedure, an expected duration of 5 minutes)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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