The effect of vitamin B5 on stress; depression and anxiety

Phase 3

Recruiting

Conditions: Type 2 diabetes.
Type 2 diabetes mellitus

Registration Number: IRCT20230702058641N2

Lead Sponsor: Shahre-kord University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 48

Inclusion Criteria

Age between 30-65 years
People who are not professional athletes.
Receiving metformin/insulin.
Patients should not take melatonin, aspirin, D3, omega3 during the study period.
Not taking oral contraceptives in the last month
people who have not received vitamin B supplements at least 3 months before the study.

Exclusion Criteria

Non-cooperation of patients to participate in the study
Use of corticosteroids and anticoagulants in the last month
Smokers
The existence of congenital cognitive and anxiety diseases
Incomplete completion of the questionnaire
People taking combined oral hypoglycemic drugs such as Sinuripa tablets
People taking drugs related to severe depression (bipolar)
People taking vitamin B5 supplements before starting the tests

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Score of depression. Timepoint: At the beginning of the study and after two months after taking vitamin B5 or placebo. Method of measurement: DASS-21 Scale.;Score of anxiety. Timepoint: At the beginning of the study and after two months after taking vitamin B5 or placebo. Method of measurement: DASS-21 Scale.;Score of stress. Timepoint: At the beginning of the study and after two months after taking vitamin B5 or placebo. Method of measurement: DASS-21 Scale.

Secondary Outcome Measures

Name	Time	Method
Cortisol level. Timepoint: At the beginning of the study and after two months. Method of measurement: ELISA technique.;Nitric oxide levels. Timepoint: At the beginning of the study and after two months. Method of measurement: Gress method.;Malondialdehyde level. Timepoint: At the beginning of the study and after two months. Method of measurement: Thiobarbituric acid method.;Antioxidant capacity. Timepoint: At the beginning of the study and after two months. Method of measurement: FRAP measurement.