NL-OMON33443尚未招募3 期
Acute and chronic administration of the folate derivate levofolinate to patients with acute myocardial infarction: A double-blinded placebo-controlled pilot study. Folate in Acute Myocardial Infarction (FolAMI-study) - FolAMI-study, Folate in Acute Myocardial Infarction.
Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 71 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 71
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •typical retrosternal pain with electocardiographic evidence for ST-elevated myocardial infarction (STEMI)
- •· Time onset angina pectoris - emergency room:<4h
- •· Age between 35-75 y
- •· Coronarographic proof of occluded/critical LAD-lesion
- •· Successful reperfusion (TIMI >= 2) after dilation and stent placing of culprit LAD-lesion
排除标准
- •· Patients with pernicious anemia or other megaloblastic anemia*s where vitamin B12 is deficient.
- •· Patients using phenobarbitone, phenytoin and primidone
- •· Phenylketonuria
- •· Exogenous administration of FA or multivitamin pills with FA >= 400µg
- •· Oncologic medical history with methotrexate administration
- •· Coronary ischemia from other reasons than atheromatose (eg. low-output syndrome, anaemia, drug-abusus)
- •· Hemodynamic Unstable patients (need for inotropica, IABP)
- •· Bradycardia (heart rate <40 beats/min).
- •· 3-vessel disease with prospection of CABG in the following 4m
- •· Medical history of immunosupression or seizures
- •· Reduced prognosis due to pre-existing comorbidity
- •· HCG-positivity or pregnancy-wish
- •· Administration of thrombolytica (full dose and/or bolus)
- •· Kidney Failure (GFR<20ml/min)
研究者
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