High Interval Versus Moderate Intensity Continuous Training on Soluble st2 Biomarkers in Chronic Heart Failure
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Heart Failure
- Sponsor
- Cairo University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- soluble ST2 biomarker level
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
This study was designed to compare between the effect of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on soluble ST2 biomarkers among chronic heart failure patients, also measure the improvement in the quality of life with different modes of exercise and with of it is more benifitial for the heart failure patient
Detailed Description
The data concerned with the study including soluble ST2 biomarker levels, ejection fraction and MLHFQ was measured before and after twelve weeks of treatment.In this study a total sixty male patients with chronic heart failure NYHA class (I \&II) were selected from the outpatient clinic, El-Demerdash hospital, Ain-shams University. Their age ranged from 50-60 years. Patients were randomly assigned into two groups, group A receiving HIIT along with prescribed medical treatment and group B receiving MCT along with prescribed medical treatment.
Investigators
Dina Reda Ali
PhD candidate
Cairo University
Eligibility Criteria
Inclusion Criteria
- •The patients selection was according to the following criteria:
- •Patients diagnosed with chronic heart failure (New York heart association class I\& II) with systolic left ventricular dysfunction.
- •Their left ventricular ejection fraction (LVEF) \<40%.
- •Medical treatment was optimized at least three months prior to study entry.
- •All patients didn't participate in any rehabilitation programs prior to the study.
Exclusion Criteria
- •Patients who had met one of the following criteria were excluded from the study:
- •Signs of acute heart failure, unstable angina or severe arrhythmia three months prior to enrolment in the study.
- •Pacemakers.
- •Chronic obstructive pulmonary disease.
- •Other disorders counteracting exercise testing conditions that limit lower limb mobility (for example, burns, fractures)
- •Pre-existing neuromuscular diseases (for example Myasthenia Gravis).
Outcomes
Primary Outcomes
soluble ST2 biomarker level
Time Frame: before the start of the trail and at the end of the trail 3 months
sample was taken at the cubited vein at the beginning of the program and also at its end
Secondary Outcomes
- ejection fraction(before the start of the trail and at the end of the trail 3 months)
- mannisota of daily living questionnaire score(before the start of the trail and at the end of the trail 3 months)
- peak exercise response(before the start of the trail and at the end of the trail 3 months)