Pulse Wave Analysis As a Functional Diagnostic Tool pre- and post percutaneous treatment for Hemodialysis Fistulas

Conditions: Z99.2
T82.9
Dependence on renal dialysis
Unspecified complication of cardiac and vascular prosthetic device, implant and graft

Registration Number: DRKS00030366

Lead Sponsor: Marien Hospital Herne, Universitätsklinikum der Ruhr-Universität Bochum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 50

Inclusion Criteria

It is planned to include patients with a native or prosthetic hemodialysis fistula who are referred to our hospital due to a malfunction of the fistula because of a possible/supposed stenosis and who are planned to get a percutaneous transluminal angioplasty (PTA) and maybe a stent implantation.
Of course there has to be a written consent of the patient.
On top of that, we will document further information like gender, age, height, weight, the renal disease as well as other illnesses and the current medication.
Also, the characterization of the fistula like the position and form will be documented.

Exclusion Criteria

Exclusion criteria are the dialysis through a Demer's catheter, a hemodynamically instability and the lack of consent of the patient.

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Slope2, Slope? and AMP will be co-primary variables (slope in the second section of the pulse wave, sum of slope in the four characteristic section of the pulse wave and amplitude of the plethysmographic measuring volume). They are going to be assessed as shunt / non-shunt inter-arm differences for Slope2 and Slope? and as inter-arm ratios for AMP.<br><br>The primary outcomes will be the differences of those arm comparing values after and before interventional treatment.

Secondary Outcome Measures

Name	Time	Method
As secondary outcome parameters we will analyze the parameters PWV, P5der1, P5der2, A1, A2, A3 and A4. (Pulse wave velocity, first and second derivative of the power spectra of the first five frequencies and areas under the pulse wave curves in the four characteristic sections). Inter-arm comparison will be assessed as differences. Values of Slope2, Slope? and AMP of patients without intervention will be included in secondary analyses.