Clinical and Histological Evaluation of Hesperidin as a Direct Pulp Capping Material

Not Applicable

Completed

• Conditions: Pulp Exposure, Dental; Dental Pulp Capping
• Interventions: Other: Hesperidin; Other: Mineral Trioxide Aggregate (MTA)

• Registration Number: NCT06402032
• Lead Sponsor: Cairo University

Brief Summary

Direct pulp capping technique is one of the oldest known treatments for exposed pulp tissue, and there is a continuous requirement for the most efficient materials to be used in this approach. Successful pulp capping is the usual way to preserve the vitality of tooth and avoid root canal treatment or surgical tooth extraction.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2022-09-01
• Primary Completion: 2023-12-01
• Study Completion: 2024-03-30
• Study First Submitted: 2024-04-30
• Status Verified: 2024-05
• Study First Submitted QC: 2024-05-03
• Last Update Submitted: 2024-05-03
• Study First Posted: 2024-05-07
• Last Update Posted: 2024-05-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• Good oral hygiene,
• Sound wisdom teeth with closed apices with normal pulp vitality response
• No periodontal disease or periapical lesions on periapical radiograph
• Cooperative patients approving to participate in the study

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Exclusion Criteria

• Medically compromised participants
• Evidence of parafunctional habits
• Heavy smokers
• Teeth with signs and symptoms of irreversible pulpitis or pulp necrosis
• Severe periodontal problems or pathological periapical changes
• Teeth with open apex or pulp calcification

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Hesperidin	Hesperidin	-
Mineral trioxide aggregate (MTA)	Mineral Trioxide Aggregate (MTA)	-

Primary Outcome Measures

Name	Time	Method
Success Rate (Clinical evaluation)	after 12 weeks	Teeth with vital pulp (numerical values with electric pulp tester) and absence of clinical signs/symptoms (Visual Analog Score for pain) as one reported value indicating clinical success rate (%)

Secondary Outcome Measures

Name	Time	Method
Histomorphometric analysis (Histologic evaluation)	after 12 weeks	Number of inflammatory cells in pulp (scores for Inflammation intensity/extensity)

Trial Locations

Locations (1)

Faculty of Dentistry Cairo University; 🇪🇬 Cairo, Egypt