Muscle properties in children with cerebral palsy undergoing orthopaedic surgical intervention to improve gait.

Recruiting

• Conditions: Cerebral palsy, range of motion, muscle, surgery; Cerebrale parese, spieren, operatie

• Registration Number: NL-OMON27577
• Lead Sponsor: VU University Medical Center, Department of Rehabilitation Medicine

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 46

Inclusion Criteria

1. Clinical diagnosis of spastic cerebral palsy;

2. Indication for surgical lengthening of thigh and/or calf muscles;

Exclusion Criteria

1. Treatment of muscles, which are indicated for surgical procedures, with Botuline A-Toxine within three months before surgery;

2. A pre-surgical treatment with selective dorsal rhizotomy, intrathecal baclofen pump or prior surgery of treated muscle;

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Histological, morphological and mechanical properties of the treated muscles and tendons, and angle-moment relationship. These will be determined by muscle and tendon biopsies, muscle ultrasound measurements and moment-angle measurements.

Secondary Outcome Measures

Name	Time	Method
Clinical, gait, and functional characteristics. Following measurements will be used: Gross Motor Function Measurement (GMFM), 6-minute walk test, Functional Mobility Scale (FMS), Mobility Questionnaire (MobQuest28), Mobility part of the Pediatric Evaluation Disability Inventory (PEDI), clinical physical examination and gait analysis.