Comparison of the Effect of Total Intravenous Anesthesia and Inhalation Anesthesia on Cancer Cell Cytotoxicity, Micrometastasis and Recurrence of Tumor in Patients Undergoing Breast Tumor Resection
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- number of NK cell
研究概览
简要总结
The purpose of this study is to compare the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity, micrometastasis and recurrence of tumor in patients undergoing breast tumor resection. Using propofol-remifentanil in total intravenous anesthesia group and sevoflurane -remifentanil in inhalation anesthesia group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •patient between 20 and 65 of age with ASA physical status Ⅰ-Ⅲ
- •breast cancer patients with no sign of local invasion (adjacent organs) and distant metastasis revealed by imaging studies
- •surgery performed by the same surgical team
排除标准
- •ASA physical status Ⅳ
- •hepatic and renal impairment
- •diabetes or other endocrine disorders
- •body mass index > 35 kg/m2
- •immune disorders or immunosuppressive therapy
- •steroid treatment in the last 6 months
- •inflammation
研究组 & 干预措施
intravenous
the total intravenous anesthesia group
干预措施: intravenous anesthesia (Procedure)
intravenous
the total intravenous anesthesia group
干预措施: propofol-remifentanil (Drug)
inhalation
the inhalation anesthesia group
干预措施: inhalation anesthesia (Procedure)
inhalation
the inhalation anesthesia group
干预措施: sevoflurane-remifentanil (Drug)
结局指标
主要结局
number of NK cell
时间窗: at 24 hour after surgery.
comparison of the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity
次要结局
未报告次要终点