Comparison of the Effect of Total Intravenous Anesthesia and Inhalation Anesthesia on Cancer Cell Cytotoxicity, Micrometastasis and Recurrence of Tumor in Patients Undergoing Breast Tumor Resection
Overview
- Phase
- Not Applicable
- Intervention
- intravenous anesthesia
- Conditions
- Breast Cancer
- Sponsor
- Yonsei University
- Enrollment
- 48
- Locations
- 1
- Primary Endpoint
- number of NK cell
- Status
- Terminated
- Last Updated
- 7 years ago
Overview
Brief Summary
The purpose of this study is to compare the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity, micrometastasis and recurrence of tumor in patients undergoing breast tumor resection. Using propofol-remifentanil in total intravenous anesthesia group and sevoflurane -remifentanil in inhalation anesthesia group.
Investigators
Eligibility Criteria
Inclusion Criteria
- •patient between 20 and 65 of age with ASA physical status Ⅰ-Ⅲ
- •breast cancer patients with no sign of local invasion (adjacent organs) and distant metastasis revealed by imaging studies
- •surgery performed by the same surgical team
Exclusion Criteria
- •ASA physical status Ⅳ
- •hepatic and renal impairment
- •diabetes or other endocrine disorders
- •body mass index \> 35 kg/m2
- •immune disorders or immunosuppressive therapy
- •steroid treatment in the last 6 months
- •inflammation
Arms & Interventions
intravenous
the total intravenous anesthesia group
Intervention: intravenous anesthesia
intravenous
the total intravenous anesthesia group
Intervention: propofol-remifentanil
inhalation
the inhalation anesthesia group
Intervention: inhalation anesthesia
inhalation
the inhalation anesthesia group
Intervention: sevoflurane-remifentanil
Outcomes
Primary Outcomes
number of NK cell
Time Frame: at 24 hour after surgery.
comparison of the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity