Comparison of the Effect of Total Intravenous Anesthesia and Inhalation Anesthesia on Cancer Cell Cytotoxicity, Micrometastasis and Recurrence of Tumor in Patients Undergoing Breast Tumor Resection

Not Applicable

Terminated

• Conditions: Breast Cancer
• Interventions: Procedure: inhalation anesthesia; Procedure: intravenous anesthesia; Drug: sevoflurane-remifentanil; Drug: propofol-remifentanil

• Registration Number: NCT02089178
• Lead Sponsor: Yonsei University

Brief Summary

The purpose of this study is to compare the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity, micrometastasis and recurrence of tumor in patients undergoing breast tumor resection. Using propofol-remifentanil in total intravenous anesthesia group and sevoflurane -remifentanil in inhalation anesthesia group.

Detailed Description

Not available

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study Start: 2014-02
• Study First Submitted: 2014-03-12
• Study First Submitted QC: 2014-03-14
• Study First Posted: 2014-03-17
• Status Verified: 2014-12
• Primary Completion: 2014-12-30
• Study Completion: 2014-12-30
• Last Update Submitted: 2019-03-15
• Last Update Posted: 2019-03-19

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Female
• Target Recruitment: 48

Inclusion Criteria

• patient between 20 and 65 of age with ASA physical status Ⅰ-Ⅲ
• breast cancer patients with no sign of local invasion (adjacent organs) and distant metastasis revealed by imaging studies
• surgery performed by the same surgical team

Read More

Exclusion Criteria

• ASA physical status Ⅳ
• hepatic and renal impairment
• diabetes or other endocrine disorders
• body mass index > 35 kg/m2
• immune disorders or immunosuppressive therapy
• steroid treatment in the last 6 months
• inflammation

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
inhalation	sevoflurane-remifentanil	the inhalation anesthesia group
inhalation	inhalation anesthesia	the inhalation anesthesia group
intravenous	intravenous anesthesia	the total intravenous anesthesia group
intravenous	propofol-remifentanil	the total intravenous anesthesia group

Primary Outcome Measures

Name	Time	Method
number of NK cell	at 24 hour after surgery.	comparison of the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity

Trial Locations

Locations (1)

Severance Hospital; 🇰🇷 Seoul, Korea, Republic of