Genetic Determinants of the Response to Salbutamol Among Asthma Patients

Not Applicable

• Conditions: Asthma

• Registration Number: NCT00162396
• Lead Sponsor: Hadassah Medical Organization

Brief Summary

The response to salbutamol varies greatly among individuals. Data from previous studies indicate that some of the variability is accounted for by genetic polymorphisms in the gene encoding for the adrenoceptor subtype β2. The current study was designed to evaluate variability in the response to salbutamol among recently diagnosed patients who have not been treated by β2 agonists or corticosteroids.

Lung function tests will be performed prior to and following a single dose administration of salbutamol through inhalation. Additional pharmacodynamic indices will be monitored including pulse and blood pressure. Three samples of plasma will be drawn for the evaluation of salbutamol plasma concentration.

Detailed Description

Not available

Study Timeline

• Study Start: 1999-08
• Study First Submitted: 2005-09-11
• Study First Submitted QC: 2005-09-11
• Study First Posted: 2005-09-13
• Status Verified: 2008-10
• Last Update Submitted: 2008-10-28
• Last Update Posted: 2008-10-29

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• 18 years and older
• Recently diagnosed as asthmatic

Exclusion Criteria

• Current treatment by β2 agonist
• Current treatment by corticosteroids
• Acute asthma attack

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Change in lung function tests after salbutamol inhalation
Change in blood pressure and pulse after salbutamol inhalation

Trial Locations

Locations (1)

Hadassah Medical Organization; 🇮🇱 Jerusalem, Israel