Magnesium sulphate in Tetanus
Completed
- Conditions
- TetanusInfections and Infestations
- Registration Number
- ISRCTN74651862
- Lead Sponsor
- niversity of Oxford (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 180
Inclusion Criteria
1. Adults with Ablett classification of tetanus severity grade three or four
2. Patient over 15 years with diagnosed tetanus
3. Tracheostomy more than six hours and not yet ventilated
Exclusion Criteria
1. Urine output less than 1 ml/kg/hr
2. Electrocardiogram (ECG) evidence of conduction abnormalities/ischaemia
3. Serum creatinine more than 1.5 mg%
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Requirement for mechanical ventilation primary outcome
- Secondary Outcome Measures
Name Time Method 1. Requirement for benzodiazepines, pipecuronium, morphine and verapamil (mg/kg)<br>2. Hourly Systolic Blood Pressure (SBP) and Heart Rate (HR) recording and mean seven day maximum SBP, HR and daily variation in SBP<br>3. In hospital mortality (including patients taken home to die)<br>4. Length of Intensive Care Unit (ICU) stay, total hospital stay and total cost of hospital stay<br>5. Requirement for ventilation during hospital stay<br>6. Daily 8 am serum Creatinine Kinase (CK) measurement<br>7. Urinary epinephrine and norepinephrine, measured from a 24 hour collection on day two of the study