Abdominal Ultrasound With Doppler and Peripheral Hemogram in Assesment Inflammatory Bowel Disease
Overview
- Phase
- Not Applicable
- Intervention
- Infliximab
- Conditions
- Inflammatory Bowel Diseases
- Sponsor
- Assiut University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- the role abdominal ultrasound in assessment inflammatory bowel disease
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
assessment of inflammatory bowel disease patients in activity and remission by abdominal ultrasound examine non-invasive and in physiological condition by measuring the colon wall thickness in diagnosis and follow up the patient also including extra intestinal features such as the splanchnic vessels,mesentery and lymph nodes . Doppler u.s can evaluate bowel wall vascularity In activity and remission . peripheral hemogram in relationship to activity inflammatory bowel disease asses anemia ,increase monocyte and decrease mean platelet volume( MPV) . also,the investigator will evaluate the outcome of different lines of treatment traditional and biologic therapy (response to treatment,times of activity and complications)
Detailed Description
the participants will follow up the patient for 1 year in the first visit All patients in this study will be subjected to: 1. Detailed history. 2. Careful physical examination 3. laboratory investigation 1. complete blood picture. 2. liver function 3. kidney function 4. Iron profile(serum iron ,serum ferritin 5. ESR (erythrocyte sedimentation rate ) g-CRP (C reactive protein) f-LDH (lactate dehydrogenase) 4. Abdominal us(the colon wall thickness,lymph nodes,mass,other organs) 5. Doppler us (mesenteric vessels) 6. colonoscopy after 1 year of treatment follow up every 3 months by abdominal US and peripheral hemogram and last visit after 1 year colonoscopy and biopsy for assessment response to treatment
Investigators
hyam fathy
clinical professor
Assiut University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
patient on traditional therapy
Drug: steroid,5ASA , immuran for assesment the outcome of therapy in inflammatory bowel disease steroid(40- 60mg tablet),5ASA(pentasa 3-4gm tablet),azathioprin (immuran 100 mg tablet)
Intervention: Infliximab
patient on infliximab
drug : infliximab (5mglkg intravenous)for the first dose,the second dose after 2 weeks the third dose after 6 weeks then every 2 months
Intervention: Infliximab
Outcomes
Primary Outcomes
the role abdominal ultrasound in assessment inflammatory bowel disease
Time Frame: 2 year
measure the thickness of the colon by abdominal ultrasound and doppler mesenteric vessels .more than 4ml detect activity doppler mesenteric highly vascularity in activity