Using markers of coronary artery disease to gain information about the disease

Not yet recruiting

Conditions: Subsequent non-ST elevation (NSTEMI) myocardial infarction,

Registration Number: CTRI/2019/03/017933

Lead Sponsor: ICMR

Brief Summary: The aim of this study is to find the correlation biomarkers of inflammation with the plaque morphology, plaque rupture and plaque erosion detected on Intravascular Imaging by Optical Coherence Tomography in acute coronary syndrome patients and six months clinical outcomes. As the there is relative high incidence of CAD in India as compared to the western population, early diagnosis with biomarkers of the vulnerable plaque or the vulnerable patient will help initiating appropriate therapy and prevent acute coronary syndromes.

The biomarkers will help to assist in making management algorithms based on the biomarkers and its correlation with type of ACS. This helps to decide as to when to initiate the medical therapy or aggressive therapy based on the correlation of biomarkers

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 140

Inclusion Criteria

1)Patients presenting with Acute Coronary syndromes (STEMI, NSTEMI, Unstable Angina with â‰¥10 minutes of angina or anginal equivalent consistent with unstable angina or myocardial infarction (MI) within 72 hours, with either elevated cardiac biomarkers (CK-MB or troponin) or ST-segment deviation of >1 mm in â‰¥2 contiguous electrocardiographic leads) to EMOPD or OPD of the Department of Cardiology at GMCH-32, will be included.

Exclusion Criteria

1.Cardiogenic shock.
2.Left Ventricular Failure (Killip Class 3 or 4).
3.Serum creatinine â‰¥2.5 mg/dl.
4.Known allergy, hypersensitivity or contraindication to aspirin, heparin, or contrast.
5.Significant gastrointestinal or urinary bleed within the past 6 weeks, coagulopathy or bleeding diathesis.
6.Deranged LFTs like bilirubin >1.5mg/dl and enzymes 2 to 3 times elevated above upper limit of normal.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Association of biomarkers of inflammation with the type of plaque morphology.	30 days.

Secondary Outcome Measures

Name	Time	Method
Correlation of the systemic biomarkers of inflammation and the coronary blood biomarkers of inflammation.	30 days.

Trial Locations

Locations (1): Govt Medical College, Cardiology dept.
🇮🇳
Chandigarh, CHANDIGARH, India
Govt Medical College, Cardiology dept.
🇮🇳Chandigarh, CHANDIGARH, India
Dr S REDDY
Principal investigator
9417495680
reddycardio2911@gmail.com