TCTR20220602005Unknown3 期
Efficacy of the ROCK inhibitor for corneal endothelial protection in Fuchs' endothelial corneal dystrophy after cataract surgery
THE 90TH ANNIVERSARY OF CHULALONGKORN UNIVERSITY FUND ( Ratchadaphiseksomphot Endowment Fund)0 个研究点目标入组 56 人开始时间: 2022年6月2日最近更新:
适应症
试验速览
- 阶段
- 3 期
- 发起方
- 入组人数
- 56
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 40 Years 至 90 Years（—）
- 性别
- All
入选标准
- •1. Age 40-90 years old
- •2. Diagnosis of FECD with modified Krachmer grade 1-4 and visual significance cataract with eligible for phacoemulsification with intraocular lens implantation
- •3. Central endothelial cell count > 1,000 cell/mm2
- •4. Paracentral endothelial cell count > 1,000 cell/mm2 in all superior /inferior/nasal/temporal quadrant
- •5. Central corneal thickness < 640 micron
- •6. Cataract grading: nuclear hardness graded by the Emery-Little classification 1-3
- •7. Willingness to regular follow-up as appointed
排除标准
- •1. History of severe ocular trauma with lens subluxation
- •2. Corneal scar
- •3. History of corneal laser vision correction
- •4. Use of ripasudil before enrollment in the study
- •5. Active allergy, infection, inflammation at ocular surface
- •6. Unstable systemic diseases: uncontrolled HT, uncontrolled DM, stroke, coronary artery disease, cerebrovascular disease, bleeding diathesis
- •7. History of allergy to ripasudil
- •8. Phacoemulsification with major intraoperative complication such as large posterior capsular tear or zonule dialysis more than 90 degrees
研究者
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