CTRI/2024/04/065756
Not yet recruiting
Phase 3
Pilot study to assess the efficacy of oral Lamivudine for macular edema due to retinal vein occlusions - NI
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Health Condition 1: H348- Other retinal vascular occlusions
- Sponsor
- Aravind Eye Hospital
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\)patients with documented presence of intraretinal or subretinal fluid secondary to Retinal Vein Occlusion.
- •2\)patients with ability and willingness to comply with treatment and follow up process and to understand and sign the informed consent form.
Exclusion Criteria
- •Study Eye only:
- •1\)Evidence of iris, anterior chamber angle or retinal/optic disc neovascularization
- •2\)Ocular disorders/additional eye disease, which in the opinion of the Investigator may confound interpretation of study results, compromise protocol assessments or are likely to require intervention during the study, including, but not limited to, atrophy of the retinal pigment epithelium, sub\-retinal fibrosis, organized hard exudate plaque, clinically significant diabetic macular edema, retinal detachment, macular hole, vitreomacular traction, macular epiretinal membrane, clinically significant cataract, vitreal opacities or hemorrhage, glaucoma with documented visual field loss, ischemic optic neuropathy, retinitis pigmentosa or choroidal neovascularization of any cause (e.g., Age\-related Macular Degeneration (AMD), ocular histoplasmosis, toxoplasmosis, or pathologic myopia)
- •3\)Receipt within the past 6 months prior to the Screening Visit of any intraocular or periocular surgery (including refractive surgery, cataract surgery), or intravitreal (IVT) injection, or planned intraocular surgery or procedure during the study
- •1\)History of glaucoma or an IOP greater than 21 mmHg
- •2\)Previous use of intraocular or periocular steroids within 3 months prior to baseline, or dexamethasone intravitreal implant within 6 months prior to baseline
- •3\)History of, or presence of uveitis, presence of intraocular inflammation
- •4\)History of intravitreal use of anti\-VEGF drugs (e.g. ranibizumab,bevacizumab,aflibercept,etc), macular laser photocoagulation (focal/grid),panretinal laser photocoagulation, vitrectomy, trabeculectomy or keratoplasty in the study eye at any time prior to baseline. YAG laser treatment or any other intraocular surgeries (e.g. cataract surgery) in the study eye within 6 months prior to the baseline
- •5\)Within 6 months prior to the Screening Visit, use of medications known to be toxic to the retina, lens, or optic nerve (e.g., desferoxamine, chloroquine/hydrochloroquine, chlorpromazine, phenothiazines, tamoxifen, and ethambutol).
- •6\)History of impaired renal or liver function
Outcomes
Primary Outcomes
Not specified
Similar Trials
Not yet recruiting
Not Applicable
Efficacy of oral scan based screening vs visual screening for oral premalignant and malignant lesioHealth Condition 1: C00-C14- Malignant neoplasms of lip, oral cavity and pharynxCTRI/2022/10/046134Dr Ravi Shankar
Recruiting
Not Applicable
A pilot study to evaluate the efficacy of lafutidine in patients with paclitaxel-induced peripheral neuropathy.gynecological cancerJPRN-UMIN000011890Fukushima medical University Hospital, School of medicine30
Not yet recruiting
Phase 2
Ayurvedic therapy for the children with autistic features.Health Condition 1: F840- Autistic disorderCTRI/2021/12/038901All India Institute of Ayurveda
Not yet recruiting
Phase 2
Effect of Praval bhasma, Lakshadi guggulu and local application of Dashang Lepa with pinda tail on knee joint pain in Hemophilia patientsCTRI/2024/01/061535Central Council for Research in Ayurvedic Sciences
Not yet recruiting
Not Applicable
A pilot study assessing the effectiveness of oral Propranolol in preventing epistasis in patients with Hereditary Haemorrhagic Telangiectasia.Hereditary Haemorrhagic TelangiectasiaHuman Genetics and Inherited Disorders - Other human genetics and inherited disordersCardiovascular - Diseases of the vasculature and circulation including the lymphatic systemACTRN12619001020178Royal brisbane and Women's Hospital15