Adipose-derived mesenchymal stem cell conditioned media in combination with crosslinked-hyaluronic acid for skin rejuvenatio

Phase 1

• Conditions: rejuvenation.; Other specified disorders of the skin and subcutaneous tissue; L98.8

• Registration Number: IRCT20230324057772N2
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 6 March 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

Male and female, age about 35 to 65 years old
Having no anatomic disorder in face
Candidate with mild to moderate wrinkles according to Glogue scale 2-4
Normal mental health based on the self assesment
Having a good cooperation with research team

Exclusion Criteria

Heavy smokers or drinkers
Applying skin rejuvination intervention in face at past 6 months or during the study
Having a mental disorder based on the self assesment
Candidate with wrinkles according to Glogue scale 1 and 5
Having an obsessed disorder
Having any related skin disorder

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantity of nasolabial fold wrinkle - Extension. Timepoint: Before the injection and after 1 and 3 months. Method of measurement: Biometry with visioface & skin sonography.;Quality of nasolabial fold wrinkle - deep. Timepoint: Before the injection and after 1 and 3 months. Method of measurement: Visio face and skin sonography.

Secondary Outcome Measures

Name	Time	Method
Skin elastisity. Timepoint: Before the intervention, 1 and 3 months. Method of measurement: Skin sonography.;Melanin level in skin. Timepoint: Before the intervention, 1 and 3 months. Method of measurement: Biometry with colorimeter.