MedPath

Assessing Effectiveness of Adalimumab for Treating Ulcerative Colitis in Real Life Conditions

Completed
Conditions
Ulcerative Colitis (UC)
Registration Number
NCT02738125
Lead Sponsor
AbbVie
Brief Summary

This study assesses the long?term effectiveness of adalimumab in subjects starting a treatment for ulcerative colitis in real life conditions, namely to describe the time to loss of clinical benefit in a time to event approach.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
265
Inclusion Criteria
  • Suffering from ulcerative colitis
  • NaΓ―ve from Adalimumab
  • Starting a treatment with adalimumab
  • Capable of and willing to grant authorization for use/disclosure of data collected
  • Able to read, understand, and complete patients questionnaires
Exclusion Criteria
  • None

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Time to loss of clinical benefitUp to Month 120

Loss of clinical benefit will be defined as one of the following: loss of efficacy leading to adalimumab discontinuation or introduction/reinforcement of aminosalicylates, 6-mercaptopurine, or azathioprine, introduction or reinforcement of corticosteroids (any route), UC-related surgery, discontinuation of adalimumab due to adverse event, death.

Secondary Outcome Measures
NameTimeMethod
Change from Baseline (Month 0) in Steroid-free remissionFrom Month 0 to Month 120

Steroid- free remission is defined as partial Mayo score \<= 2 with no subscore \>1 and no daily intake of prednisone.

Change from Baseline (Month 0) in Clinical RemissionFrom Month 0 to Month 120

Clinical remission is defined as partial Mayo score \<= 2 with no subscore \>1

Change from Baseline (Month 0) in Clinical ResponseFrom Month 0 to Month 120

Clinical response is decrease in partial Mayo score \>= 3 points and \>= 30% from baseline plus a decrease in rectal bleeding subscore \>= 1 or an absolute rectal bleeding subscore \<= 1.

Trial Locations

Locations (80)

CHU La RΓ©union - site St Denis - FΓ©lix-Guyon /ID# 151556

πŸ‡«πŸ‡·

Saint-Denis, France

Cabinet Medical /ID# 155460

πŸ‡«πŸ‡·

BAIE Mahault, Guadeloupe, France

CHU Toulouse - Hopital Purpan /ID# 167179

πŸ‡«πŸ‡·

TOULOUSE Cedex 9, Haute-Garonne, France

CHRU Nancy - HΓ΄pitaux de Brabois /ID# 151147

πŸ‡«πŸ‡·

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, France

HCL - Hopital Edouard Herriot /ID# 151513

πŸ‡«πŸ‡·

Lyon, France

Ch Chauny /Id# 151149

πŸ‡«πŸ‡·

Chauny, France

Hopital Louis Mourier,Colombes /ID# 152650

πŸ‡«πŸ‡·

Colombe, France

Cabinet Medical /ID# 151092

πŸ‡«πŸ‡·

Plerin, France

Cabinet Medical /ID# 151555

πŸ‡«πŸ‡·

Prades-le-lez, France

Cabinet Medical /ID# 151093

πŸ‡«πŸ‡·

Plerin, France

Centre de Consultations /ID# 155458

πŸ‡«πŸ‡·

St Nazaire, France

Maison de SantΓ© Protestante Bordeaux Bagatelle /ID# 151497

πŸ‡«πŸ‡·

Talence CEDEX, France

Cabinet Medical /ID# 152841

πŸ‡«πŸ‡·

Toulouse, France

Duplicate_Hopital Trousseau /ID# 150168

πŸ‡«πŸ‡·

Tours, France

HCL - HΓ΄pital Lyon Sud /ID# 151505

πŸ‡«πŸ‡·

Pierre Benite CEDEX, Auvergne-Rhone-Alpes, France

CH Henri Duffaut /ID# 151383

πŸ‡«πŸ‡·

Avignon CEDEX 9, Provence-Alpes-Cote-d Azur, France

Pole Sante Leonard de Vinci /ID# 151384

πŸ‡«πŸ‡·

Chambray Les Tours, France

Hopital de la Cavale Blanche /ID# 152618

πŸ‡«πŸ‡·

Brest, France

Geier, Cabinet Medical /ID# 149652

πŸ‡«πŸ‡·

Brest, France

CH du Haut Anjou /ID# 151151

πŸ‡«πŸ‡·

Chateau Gontier, France

Cabinet Medical /ID# 151162

πŸ‡«πŸ‡·

Strasbourg, France

Clinique Ambroise Pare /ID# 161978

πŸ‡«πŸ‡·

Toulouse, France

AP-HP - Hopital Bichat - Claude-Bernard /ID# 151176

πŸ‡«πŸ‡·

Paris, France

Centre Medical Alexandre Dumas /Id# 165857

πŸ‡«πŸ‡·

Amiens, France

Duplicate_HOPITAL DUPUYTREN /ID# 157889

πŸ‡«πŸ‡·

Limoges, France

Centre Endo Nord Isere /ID# 151390

πŸ‡«πŸ‡·

Bourgoin Jallieu, France

CH Annecy Genevois Site Annecy /ID# 151131

πŸ‡«πŸ‡·

PRINGY cedex, Haute-Savoie, France

Duplicate_Hopital Robert Ballanger /ID# 151382

πŸ‡«πŸ‡·

Aulnay Sous Bois Cedex, France

Centre Hospitalier de la Cote /ID# 163714

πŸ‡«πŸ‡·

Bayonne, Pyrenees-Atlantiques, France

APHM - Hopital Nord /ID# 152620

πŸ‡«πŸ‡·

Marseille, Bouches-du-Rhone, France

Hopital Beaujon /ID# 151498

πŸ‡«πŸ‡·

Clichy, Ile-de-France, France

CH La Rochelle - Hopital Saint Louis /ID# 151182

πŸ‡«πŸ‡·

La Rochelle, France

Duplicate_CHU LYON SUD /ID# 153801

πŸ‡«πŸ‡·

Pierre Benite, France

Hopital de la Cavale Blanche /ID# 153608

πŸ‡«πŸ‡·

Brest, France

CHRU Lille - Hopital Claude Huriez /ID# 151514

πŸ‡«πŸ‡·

Lille, Hauts-de-France, France

Cabinet Medical /ID# 151391

πŸ‡«πŸ‡·

Caen, France

Polyclinique du Tondu /ID# 161977

πŸ‡«πŸ‡·

Bordeaux, France

Centre Medical Les Sources /ID# 151174

πŸ‡«πŸ‡·

Montigny Les Cormeilles, France

AP-HP - Hopital Saint-Louis /ID# 151509

πŸ‡«πŸ‡·

Paris, France

Hopital Paris Saint-Joseph /ID# 153526

πŸ‡«πŸ‡·

Paris, France

Cabinet Medical /ID# 152362

πŸ‡«πŸ‡·

Paris, France

Cabinet Medical /ID# 151094

πŸ‡«πŸ‡·

Plerin, France

Cabinet Medical /ID# 150978

πŸ‡«πŸ‡·

Douarnenez, France

Centre Gastro Loire /ID# 151387

πŸ‡«πŸ‡·

Gien, France

Cabinet Medical /ID# 151148

πŸ‡«πŸ‡·

Poissy, France

Cabinet Medical /ID# 151558

πŸ‡«πŸ‡·

Saverne, France

Centre de Consultations /ID# 151128

πŸ‡«πŸ‡·

St Nazaire, France

GH Mutualiste Les Portes Du Sud /ID# 152374

πŸ‡«πŸ‡·

Venissieux, France

CHU d'Amiens /ID# 152651

πŸ‡«πŸ‡·

Salouel, France

Centre de Consultations /ID# 151164

πŸ‡«πŸ‡·

St Nazaire, France

Cabinet Medical /ID# 151559

πŸ‡«πŸ‡·

St Quentin, France

CHU Toulouse - Hopital Rangueil /ID# 157890

πŸ‡«πŸ‡·

Toulouse, France

GH Mutualiste Les Portes Du Sud /ID# 159231

πŸ‡«πŸ‡·

Venissieux, France

Centre HΓ©pato-Biliaire - Hopital Paul-Brousse /ID# 151152

πŸ‡«πŸ‡·

Villejuif, France

Cabinet Medical /ID# 151118

πŸ‡«πŸ‡·

Paris, France

Cabinet Medical /ID# 150845

πŸ‡«πŸ‡·

Erstein, France

GHPSO CH Creil /ID# 151117

πŸ‡«πŸ‡·

Creil, France

Cabinet Medical /ID# 170136

πŸ‡«πŸ‡·

Toulouse, France

Clinique du Palais /ID# 151175

πŸ‡«πŸ‡·

Grasse, France

Cabinet Medical, Dr. Constant, /ID# 151119

πŸ‡«πŸ‡·

Toulon, France

Cabinet Medical /ID# 151557

πŸ‡«πŸ‡·

Troyes, France

Clinique Pasteur /ID# 155792

πŸ‡«πŸ‡·

Toulouse CEDEX 3, France

Chu de Nice-Hopital L'Archet Ii /Id# 151132

πŸ‡«πŸ‡·

Nice, Alpes-Maritimes, France

CHU Clermont-Ferrand /ID# 153527

πŸ‡«πŸ‡·

Clermont, Auvergne-Rhone-Alpes, France

HCL - HΓ΄pital Lyon Sud /ID# 151146

πŸ‡«πŸ‡·

Pierre Benite CEDEX, Auvergne-Rhone-Alpes, France

Hopital Saint Joseph /ID# 164405

πŸ‡«πŸ‡·

Marseille, Bouches-du-Rhone, France

HCL - HΓ΄pital Lyon Sud /ID# 165859

πŸ‡«πŸ‡·

Pierre Benite CEDEX, Auvergne-Rhone-Alpes, France

CH Henri Duffaut /ID# 151499

πŸ‡«πŸ‡·

Avignon CEDEX 9, Provence-Alpes-Cote-d Azur, France

CHRU Tours - Hopital Trousseau /ID# 163503

πŸ‡«πŸ‡·

Chambray Les Tours, France

CHU Grenoble - Hopital Michallon /ID# 151508

πŸ‡«πŸ‡·

La Tronche, France

CH Des Deux Vallees Longumeau /ID# 150977

πŸ‡«πŸ‡·

Longjumeau, France

CHRU Pontchaillou /ID# 166806

πŸ‡«πŸ‡·

Rennes, France

Centre Medical du Clos de Pacy /ID# 151129

πŸ‡«πŸ‡·

Sucy En Brie, France

Clinique Pasteur /ID# 151088

πŸ‡«πŸ‡·

Toulouse CEDEX 3, France

Cabinet Medical /ID# 152617

πŸ‡«πŸ‡·

Voiron, France

CHU NIMES - Hopital Caremeau /ID# 169178

πŸ‡«πŸ‡·

Nimes CEDEX 9, Gard, France

Centre Hosp Intercommunal de Creteil /ID# 152361

πŸ‡«πŸ‡·

Creteil, Val-de-Marne, France

Chu de Nice-Hopital L'Archet Ii /Id# 151181

πŸ‡«πŸ‡·

Nice, Alpes-Maritimes, France

CHU de SAINT ETIENNE - Hopital Nord /ID# 166807

πŸ‡«πŸ‡·

St. Priest En Jarez, Loire, France

Centre des consultations spΓ©cialisΓ©es de la sauvegarde /ID# 151515

πŸ‡«πŸ‡·

Lyon, France

Β© Copyright 2025. All Rights Reserved by MedPath