A Randomized, Multi-center, Double-Blind, Controlled, Parallel Design, Phase II Study to Evaluate the Efficacy and Safety Administration by Doses of BR1400-1, BR1400-2, BR1400-3, BR1400-4, and BR1400-5 in Patients With Essential Hypertension
Overview
- Phase
- Phase 2
- Status
- Not yet recruiting
- Enrollment
- 330
- Locations
- 1
- Primary Endpoint
- Change from baseline to treatment of 8 weeks in MSSBP
Overview
Brief Summary
The objective of this clinical trial is to evaluate the antihypertensive efficacy and safety of BR1400-1, BR1400-2, BR1400-3, BR1400-4, and BR1400-5 with essential hypertension.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 19 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •\<Screening Visit (V1)\>
- •Patients with essential hypertension whose mean sitting systolic blood pressure (MSSBP) measured in the reference arm at the screening (Visit 1) meets the following criteria:
- •For patients not currently receiving antihypertensive therapy: 140 mmHg ≤ MSSBP \< 180 mmHg
- •For patients receiving antihypertensive therapy : 130 mmHg ≤ MSSBP \< 180 mmHg
- •For patients receiving antihypertensive therapy at the screening (Visit 1), those for whom the investigator determines that it is medically appropriate to temporarily discontinue their current antihypertensive treatment during the study.
- •\<Baseline Visit (V2)\>
- •Patients with essential hypertension whose mean sitting systolic blood pressure (MSSBP) measured in the reference arm at the baseline (Visit 2) prior to randomization meets the following criteria:
- •For patients without cardiovascular disease: 140 mmHg ≤ MSSBP \< 180 mmHg
- •For patients with cardiovascular disease, diabetes with cardiovascular disease, albuminuria, or diabetes with chronic kidney disease (CKD): 130 mmHg ≤ MSSBP \< 180 mmHg
Exclusion Criteria
- •Patients with blood pressure results showing MSSBP ≥ 180 mmHg or MSDBP ≥ 110 mmHg at screening(V1) and baseline(V2)
- •Patients with a history of secondary hypertension or suspected secondary hypertension; (e.g., coarctation of the aorta, hyperaldosteronism, renal artery stenosis, renal hypertension, pheochromocytoma, Cushing's syndrome and polycystic kidney disease, etc.)
- •Patients with shock
- •Patients with orthostatic hypotension accompanied by symptoms
Arms & Interventions
BR1400-3 + BR1400-B + BR1400-C
Patients will receive BR1400-3 + BR1400-B (Placebo of BR1400-2 & BR1400-4) + BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-3 (Drug)
BR1400-1 + BR1400-B + BR1400-C
Patients will receive tablet BR1400-1 + BR1400-B (Placebo of BR1400-2 & BR1400-4)+ BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-1 (Drug)
BR1400-1 + BR1400-B + BR1400-C
Patients will receive tablet BR1400-1 + BR1400-B (Placebo of BR1400-2 & BR1400-4)+ BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-B (Drug)
BR1400-1 + BR1400-B + BR1400-C
Patients will receive tablet BR1400-1 + BR1400-B (Placebo of BR1400-2 & BR1400-4)+ BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-C (Drug)
BR1400-A + BR1400-2 + BR1400-C
Patients will receive BR1400-A (Placebo of BR1400-1 & BR1400-3) + BR1400-2 + BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-2 (Drug)
BR1400-A + BR1400-2 + BR1400-C
Patients will receive BR1400-A (Placebo of BR1400-1 & BR1400-3) + BR1400-2 + BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-A (Drug)
BR1400-A + BR1400-2 + BR1400-C
Patients will receive BR1400-A (Placebo of BR1400-1 & BR1400-3) + BR1400-2 + BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-C (Drug)
BR1400-3 + BR1400-B + BR1400-C
Patients will receive BR1400-3 + BR1400-B (Placebo of BR1400-2 & BR1400-4) + BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-B (Drug)
BR1400-3 + BR1400-B + BR1400-C
Patients will receive BR1400-3 + BR1400-B (Placebo of BR1400-2 & BR1400-4) + BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-C (Drug)
BR1400-A + BR1400-4 + BR1400-C
Patients will receive BR1400-A (Placebo of BR1400-1 & BR1400-3) + BR1400-4 + BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-4 (Drug)
BR1400-A + BR1400-4 + BR1400-C
Patients will receive BR1400-A (Placebo of BR1400-1 & BR1400-3) + BR1400-4 + BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-A (Drug)
BR1400-A + BR1400-4 + BR1400-C
Patients will receive BR1400-A (Placebo of BR1400-1 & BR1400-3) + BR1400-4 + BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-C (Drug)
BR1400-A + BR1400-B + BR1400-5
Patients will receive BR1400-A (Placebo of BR1400-1 & BR1400-3) + BR1400-B (Placebo of BR1400-2 & BR1400-4) + BR1400-5
Intervention: BR1400-5 (Drug)
BR1400-A + BR1400-B + BR1400-5
Patients will receive BR1400-A (Placebo of BR1400-1 & BR1400-3) + BR1400-B (Placebo of BR1400-2 & BR1400-4) + BR1400-5
Intervention: BR1400-A (Drug)
BR1400-A + BR1400-B + BR1400-5
Patients will receive BR1400-A (Placebo of BR1400-1 & BR1400-3) + BR1400-B (Placebo of BR1400-2 & BR1400-4) + BR1400-5
Intervention: BR1400-B (Drug)
BR1400-A + BR1400-B + BR1400-C
Patients will receive BR1400-A (Placebo of BR1400-1 & BR1400-3) + BR1400-B (Placebo of BR1400-2 & BR1400-4) + BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-A (Drug)
BR1400-A + BR1400-B + BR1400-C
Patients will receive BR1400-A (Placebo of BR1400-1 & BR1400-3) + BR1400-B (Placebo of BR1400-2 & BR1400-4) + BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-B (Drug)
BR1400-A + BR1400-B + BR1400-C
Patients will receive BR1400-A (Placebo of BR1400-1 & BR1400-3) + BR1400-B (Placebo of BR1400-2 & BR1400-4) + BR1400-C (Placebo of BR1400-5)
Intervention: BR1400-C (Drug)
Outcomes
Primary Outcomes
Change from baseline to treatment of 8 weeks in MSSBP
Time Frame: 8 weeks
Secondary Outcomes
No secondary outcomes reported