Comparison of the effectiveness of Intralesional Methotrexate with Intralesional Triamcinolone Acetonide in the treatment of Localized Alopecia Areata of the scalp - A Randomized controlled Trial.
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- To Compare the effectiveness of Intralesional Methotrexate and Intralesional Triamcinolone Acetonide in the treatment of localized Alopecia areata of the scalp clinically using SALT score and Regrowth scale.
研究概览
简要总结
Alopecia areata (AA) is an autoimmune disorder characterized by clearly defined areas of non-scarring hair loss. Various therapeutic modalities are present such as corticosteroids, phototherapy, anthralin, topical minoxidil, immunotherapy with varying response.Intralesional( I/L) Triamcinolone Acetonide (TrA) is regarded as the preferred treatment for Localized AA in adults involving less than 50% of the scalp, although it has numerous adverse effects. Systemic MTX has been successfully used to treat AA, although it comes with a number of adverse effects and requires periodic laboratory monitoring.So, our aim is to evaluate the efficacy of intralesional MTX as a therapeutic option compared to Triamcinolone acetonide
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Adult patients with Localized Alopecia Areata of the scalp with ≤ 3 patches 2.Patients who did not receive any specific treatment for Alopecia Areata or regrowth of hair during the last 3 months.
排除标准
- •1.Pregnant and lactating women 2.Chronic hepatic or hematological disorders 3.Patients on systemic corticosteroids or other Immunosuppressants 4.Local infections.
结局指标
主要结局
To Compare the effectiveness of Intralesional Methotrexate and Intralesional Triamcinolone Acetonide in the treatment of localized Alopecia areata of the scalp clinically using SALT score and Regrowth scale.
时间窗: Sessions will be repeated every 3 weeks for maximum three sessions(0,3,6weeks) and patient will be evaluated at 9th week and12th week.
次要结局
- To compare the Trichoscopic changes following treatment of localized alopecia areata of scalp with Intralesional Methotrexate & Intralesional Triamcinolone Acetonide.(Sessions will be repeated every 3 weeks for maximum three sessions(0,3,6weeks) & patient will be evaluated at 9th week and12th week.)