Comparison of the effectiveness of Intralesional Methotrexate with Intralesional Triamcinolone Acetonide in the treatment of Localized patchy hair loss of the scalp.

Phase 1

Not yet recruiting

Conditions: Alopecia areata,

Registration Number: CTRI/2024/08/072542

Lead Sponsor: Karthiyaini A

Brief Summary: Alopecia areata (AA) is an autoimmune disorder characterized by clearly defined areas of non-scarring hair loss. Various therapeutic modalities are present such as corticosteroids, phototherapy, anthralin, topical minoxidil, immunotherapy with varying response.Intralesional( I/L) Triamcinolone Acetonide (TrA) is regarded as the preferred treatment for Localized AA in adults involving less than 50% of the scalp, although it has numerous adverse effects. Systemic MTX has been successfully used to treat AA, although it comes with a number of adverse effects and requires periodic laboratory monitoring.So, our aim is to evaluate the efficacy of intralesional MTX as a therapeutic option compared to Triamcinolone acetonide

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 70

Inclusion Criteria

1.Adult patients with Localized Alopecia Areata of the scalp with â‰¤ 3 patches 2.Patients who did not receive any specific treatment for Alopecia Areata or regrowth of hair during the last 3 months.

Exclusion Criteria

1.Pregnant and lactating women 2.Chronic hepatic or hematological disorders 3.Patients on systemic corticosteroids or other Immunosuppressants 4.Local infections.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To Compare the effectiveness of Intralesional Methotrexate and Intralesional Triamcinolone Acetonide in the treatment of localized Alopecia areata of the scalp clinically using SALT score and Regrowth scale.	Sessions will be repeated every 3 weeks for maximum three sessions(0,3,6weeks) and patient will be evaluated at 9th week and12th week.

Secondary Outcome Measures

Name	Time	Method
To compare the Trichoscopic changes following treatment of localized alopecia areata of scalp with Intralesional Methotrexate & Intralesional Triamcinolone Acetonide.	Sessions will be repeated every 3 weeks for maximum three sessions(0,3,6weeks) & patient will be evaluated at 9th week and12th week.

Trial Locations

Locations (1): AARUPADAI VEEDU MEDICAL COLLEGE AND HOSPITAL
🇮🇳
Pondicherry, PONDICHERRY, India
AARUPADAI VEEDU MEDICAL COLLEGE AND HOSPITAL
🇮🇳Pondicherry, PONDICHERRY, India
Dr Karthiyaini A
Principal investigator
8110883943
yainijessie1997@gmail.com