Glycaemic Response and Insulinaemic Response for Nutralys S85 Plus and Whey Protein
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Area under the blood glucose concentration versus time curve
研究概览
简要总结
A comparison of the glycaemic response and insulinaemic response to glucose, Nutralys S85 Plus pea protein and whey protein using a single-blind, randomised, repeat measure, crossover design trial.
详细描述
A single-blind, randomised, repeat measure, crossover design trial will be used to study the glycaemic response and insulinaemic response following consumption of five products: one reference product (50 g available carbohydrate Glucose) and four test products (50 g available carbohydrate Glucose with 10 g NUTRALYS®S85 Plus pea protein, 50 g available carbohydrate Glucose with 20 g NUTRALYS®S85 Plus pea protein, 50 g available carbohydrate Glucose with 10 g Whey protein concentrate and 50 g available carbohydrate Glucose with 20 g Whey protein concentrate).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
single-blind
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 18 to 60 years
- •Body mass index (BMI) less than 30kg/m2
排除标准
- •Pregnant or lactating
- •Fasting blood glucose value > 6.1 mmol/l
- •Any known food allergy or intolerance
- •Medical condition(s) or medication(s) known to affect glucose regulation or appetite and/or which influence digestion and absorption of nutrients
- •Known history of diabetes mellitus or the use of antihyperglycaemic drugs or insulin to treat diabetes and related conditions
- •Major medical or surgical event requiring hospitalization within the preceding 3 months
- •Use of steroids, protease inhibitors or antipsychotics (all of which have major effects on glucose metabolism and body fat distribution)
- •Unable to comply with experimental procedures or did not follow GR testing safety guidelines.
结局指标
主要结局
Area under the blood glucose concentration versus time curve
时间窗: 3 hours
Area under the blood glucose concentration versus time curve was calculated by trapezoidal rule
Area under the plasma insulin concentration versus time curve
时间窗: 3 hours
Area under the plasma insulin concentration versus time curve was calculated by trapezoidal rule
Change in plasma insulin response from baseline for 3 hours
时间窗: 3 hours
Change in postprandial plasma insulin response from baseline was measured at 15 min, 30 min, 45 min, 1 hour, 1.5 hours, 2 hours, 2.5 hours and 3 hours
Time of plasma insulin peak (Tmax)
时间窗: 0-3 hours
Time of plasma insulin peak after consumption of the test food
Change in blood glucose response from baseline for 3 hours
时间窗: 3 hours
Change in postprandial blood glucose response from baseline was measured at 15 min, 30 min, 45 min, 1 hour, 1.5 hours, 2 hours, 2.5 hours and 3 hours
Peak plasma insulin concentration (Cmax)
时间窗: 0-3 hours
Peak plasma insulin concentration (Cmax) after consumption of the test food
Time of blood glucose peak (Tmax)
时间窗: 0-3 hours
Time of blood glucose peak after consumption of the test food
Peak blood glucose concentration (Cmax)
时间窗: 0-3 hours
Peak blood glucose concentration (Cmax) after consumption of the test food
次要结局
未报告次要终点
研究者
Dr. Sangeetha Thondre
Principal Investigator
Oxford Brookes University