Intrahospital transport of critically ill patients using high flow nasal cannula or non invasive ventilation: A randomised comparative study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- 1) To determine the effect on oxygenation, by measuring SpO2
研究概览
简要总结
Intra-hospital transfers on NIV/HFC patients are usually made:
a) From the emergency department (ED) to the ICU or to another
high-intensity ward with experience in handling NIV/HFNC (e.g., The
respiratory intermediate care unit),
b) Between the ED or the ICU and the radiology department; and
c) Between the ED/ICU and specialized care units, such as the
endoscopic or hemodynamic unit.
However, moving patients from the safety of an intensive care unit
(ICU) or other high-intensity care units is associated with an overall
complication rate of up to 70% and a mortality rate of 2% .
Mechanical ventilation, with its requirement of specific equipment and
expertise, might further increase the incidence of transport-related
adverse events.
Non-invasive mechanical ventilation (NIV) and High Flow Nasal
Cannula (HFNC) have been proven to be effective in patients with acute
respiratory failure (ARF) of various etiologies.
Intra-hospital transfers of patients on NIV have become an increasingly
common occurrence. Today, there is a wide range of ventilators offering
the opportunity to apply both conventional invasive and non-invasive
mechanical ventilation.
While unexpected events during the intra-hospital transfer of critical
patients receiving conventional ventilation have been extensively
reviewed, few recommendations regarding patients receiving NIV
and HFNC support are available.
The use of NIV and HFNC for the intrahospital transport of patients
has not been studied in detail. Thus, the present prospective,
randomized, controlled trial compares the efficacy of HFNC versus
NIV in the transportation of critically ill patients with acute
respiratory failure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Age 18 years or above 2) Critically ill patients requiring intra- hospital transport.
排除标准
- •Severe respiratory failure requiring immediate tracheal intubation (respiratory frequency 40 times/min, severe hypoxia, severe respiratory acidosis with a ph <7.25, glasgow score <8).
- •A contraindication to NIV (oral and facial trauma, excessive phlegm with poor expectoration ability, hemodynamic instability).
- •Patients with poor short term prognosis (very high risk of death within seven days or receiving palliative care).
- •Pregnant women.
- •Carriers of an implantable defibrillator or pacemaker.
- •Tracheostomized patients.
结局指标
主要结局
1) To determine the effect on oxygenation, by measuring SpO2
时间窗: 1) during tansportation of patient | 2) 5 minutes, 15 minutes, 1 hour, 24 hours, 48 hours after transport.
during transportation.
时间窗: 1) during tansportation of patient | 2) 5 minutes, 15 minutes, 1 hour, 24 hours, 48 hours after transport.
2) To determine the need to escalate/de-escalate respiratory
时间窗: 1) during tansportation of patient | 2) 5 minutes, 15 minutes, 1 hour, 24 hours, 48 hours after transport.
support/ invasive mechanical ventilation after ICU admission.
时间窗: 1) during tansportation of patient | 2) 5 minutes, 15 minutes, 1 hour, 24 hours, 48 hours after transport.
次要结局
- to record:(1.duration of respiratory support.)