Safety and Efficacy of ABT-510 in Subjects With Advanced Renal Cell Carcinoma
- Conditions
- Carcinoma, Renal Cell
- Registration Number
- NCT00073125
- Lead Sponsor
- Abbott
- Brief Summary
The primary objective of this study is to assess the safety and efficacy of ABT-510 in subjects with advanced renal cell carcinoma.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 103
A subject will be eligible for study participation if all of the following criteria are met:
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The subject is at least 18 years of age.
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The subject has advanced histologically documented renal cell carcinoma. Advanced disease is defined as locally recurrent disease or metastatic disease that is not amendable to curative resection.
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The subject has not received prior therapy (anti-tumor radiotherapy, immunotherapy, chemotherapy, or investigational therapy) for metastatic renal cell carcinoma other than excision of primary tumor where appropriate. Local radiation for supportive reasons will be allowed; however, not within 28 days from Study Day 1.
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The subject has an Eastern Cooperative Oncology Group (ECOG) Performance Score of 0-1
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The subject is able to self-administer or has a caregiver who can reliably administer subcutaneous injections.
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The subject must have adequate bone marrow, renal, and hepatic function as follows:
- Bone Marrow: White blood cell count (WBC) ≥ 3,000/mm3 (3.0 X 109/L); Platelets ≥ 100,000/mm3 (100 X 109/L); Hemoglobin ≥ 9.0 g/dL (1.4 mmol/L)
- Renal function: serum creatinine ≤ 2.0 mg/dL (0.81 mmol/L)
- Hepatic function: AST and ALT ≤ 1.5 X ULN unless liver metastases are present, then AST and ALT ≤ 5.0 X ULN; LDH ≤ 1.5 X ULN; bilirubin ≤ 1.5 mg/dL (0.026 mmol/L) Corrected calculated calcium ≤ 10 mg/dL (2.5 mmol/L) Calculation = total calcium - 0.707 (albumin -3.4)Albumin ≥ 3.0 g/dL (0.45 mmol/L)
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The subject must not be pregnant or lactating and all subjects (male and female) must use a contraceptive method deemed acceptable by the investigator while in the study and for up to two months following completion of therapy.
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The subject has voluntarily signed and dated an Institutional Review Board (IRB)/Independent Ethics Committee (IEC) approved consent prior to any study specific procedures.
A subject will be ineligible for study participation if any of the following criteria are met:
- The subject has a history of or currently exhibits Central Nervous System (CNS) metastasis. Brain MRI within 28 days of enrollment is required to confirm absence of CNS metastases.
- The subject is receiving therapeutic anticoagulation therapy. Low dose anticoagulation (e.g., low dose Coumadin) for catheter prophylaxis will be permitted; PT/PTT must be within normal limits.
- The subject has a history of or currently exhibits clinically significant cancer related events of bleeding (e.g., hemoptysis). The subject has a recent history of (within 4 weeks of Study Day 1) or currently exhibits other clinically significant signs of bleeding.
- The subject exhibits evidence of clinically significant uncontrolled conditions(s) and/or is considered by the investigator to be unable to tolerate the proposed treatment or procedures.
- The subject has history of other previous malignancies within 5 years, with the exception of: Adequately treated in situ carcinoma of the cervix uteri or Basal or squamous cell carcinoma of the skin
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Progression free survival One year
- Secondary Outcome Measures
Name Time Method Performance status One year Overall survival One year Response rate One year
Trial Locations
- Locations (17)
Arizona Cancer Center
🇺🇸Tucson, Arizona, United States
Virginia G. Piper Cancer Center
🇺🇸Scottsdale, Arizona, United States
UCLA School of Medicine
🇺🇸Los Angeles, California, United States
Clinical Trials and Research Associates
🇺🇸Montebello, California, United States
University of Chicago Medical Center
🇺🇸Chicago, Illinois, United States
The Center for Hematology-Oncology
🇺🇸Boca Raton, Florida, United States
Central indiana Cancer Center
🇺🇸Indianapolis, Indiana, United States
University of Michigan
🇺🇸Ann Arbor, Michigan, United States
Kansas City Oncology and Hematology Group
🇺🇸Kansas City, Missouri, United States
Albany Regional Cancer Center
🇺🇸Albany, New York, United States
Raleigh Hematology Oncology Clinic
🇺🇸Cary, North Carolina, United States
US Oncology, P.A.
🇺🇸Dallas, Texas, United States
Texas Cancer Center
🇺🇸Fort Worth, Texas, United States
MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States
Academic Hospital Groningen
🇳🇱Groningen, Netherlands
Kansas City Cancer Centers Southwest
🇺🇸Overland Park, Kansas, United States