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Clinical Trials/CTRI/2021/05/033642
CTRI/2021/05/033642
Recruiting
Phase 3

Total Neoadjuvant Therapy for Locally Advanced Rectal Carcinoma: A Multicentric Randomized Controlled Trial - TNT-LARC

Medical College Kolkata0 sites0 target enrollmentTBD
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ConditionsHealth Condition 1: C20- Malignant neoplasm of rectum

Overview

Phase
Phase 3
Intervention
Not specified
Conditions
Health Condition 1: C20- Malignant neoplasm of rectum
Sponsor
Medical College Kolkata
Status
Recruiting
Last Updated
3 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
3 years ago
Study Type
Interventional

Investigators

Eligibility Criteria

Inclusion Criteria

  • •1\. Clinically and radiologically stage T3 and T4 rectal carcinoma.
  • •2\. Any T stage with lymph node positive on imaging.
  • •3\. Tumour located within 12cm of anal verge.
  • •4\. ECOG performance scale 0\-2

Exclusion Criteria

  • •1\. Metastatic disease
  • •2\. History of previous pelvic irradiation or
  • •chemotherapy for rectal carcinoma.
  • •3\. Synchronous malignancy.
  • •4\. Associated colonic polyposis.
  • •5\. Obvious or suspected intestinal obstruction
  • •(eligible if proximal diversion stoma
  • •relieved the obstruction).
  • •6\. Any serious medical comorbid condition that
  • •precludes systemic therapy.

Outcomes

Primary Outcomes

Not specified

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