Impact of inflammatory cytokines to CYP3A or OATP1B activities in rheumatoid arthritis patient using endogenous substrate.
Not Applicable
- Conditions
- rheumatoid arthritis
- Registration Number
- JPRN-UMIN000034715
- Lead Sponsor
- Oita University Hospital, Department of Clinical Pharmacy
- Brief Summary
37 outpatients with RA were analyzed. OATP1B115 carriers tended to have higher CP-I concentration compared to non-carriers. Plasma CP-I correlated positively with CMPF concentration, but did not correlate with IL-6 or TNF-alpha concentration. Multiple logistic regression analysis by stepwise selection identified plasma CMPF concentration and OATP1B115 allele as significant factors independently affecting plasma CP-I concentration at baseline and at the next visit, respectively.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 37
Inclusion Criteria
Not provided
Exclusion Criteria
Not applicable
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method