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临床试验/NCT00430404
NCT00430404已完成4 期

Randomized Controlled Trial of a Community-based Early Psychiatric Intervention Strategy to Screen and Manage Depression in the Elderly

National University Hospital, Singapore2 个研究点 分布在 1 个国家目标入组 214 人开始时间: 2004年8月最近更新:
适应症

试验速览

阶段
4 期
状态
已完成
入组人数
214
试验地点
2
主要终点
Response to treatment at 6 months follow up is defined as a 50% reduction in HAMD-17 score

研究概览

简要总结

To evaluate the effectiveness of a community-based strategy of routine population mass screening for depression with follow-up feedback and management in a primary care non-psychiatric setting involving a structured, multifaceted, collaborative (primary care and hospital-based)shared care programme.

Hypotheses:

We hypothesize that a community-based early psychiatric interventional strategy (CEPIS) for depression in the elderly leads to increased recognition of depression by primary care physicians, more initiation of treatment for emotional problems, and improved outcomes for patients with depression, as measured by:

  1. increased rates of detection or recognition by a primary care physician of minor or major (clinical) depression.
  2. higher rates of management activities: counselling for psychological, family social problems, contact with community family services (human service agency), consultation and/or referral to a mental health specialist
  3. Reduced depressive symptom severity, improved level of daily functioning and quality of life among those with major clinical depression
  4. Better patient satisfaction with care
  5. Favourable clinician's and patients perception of their usefulness or acceptability

详细描述

Depression is a highly prevalent, clinically under-recognized and under-treated medical disorder world wide. In Singapore, 17% of the adult population experience recent psychiatric disturbances, yet only 6% use the services of any health professional. General practitioners are the most commonly preferred caregiver, and actually used by 41.1% of those who sought help. At the same time, suicide rates especially among the elderly remain at very high levels compared to other countries in the world.

In recent decades, screening questionnaires have been developed and validated that are suitable for the initial detection of depression in the primary care setting. Previous research have shown that screening for depression do not result in increased recognition rates of mental disorders unless positive cases are selectively fed back to primary care physicians. They also do not translate into increased rates of interventional activities such as initiation of therapy and referral to mental health specialists. Neither dose primary care physician education or clinical practice guidelines result in any improved outcomes for the patients unless these are accompanied by more sophisticated strategies in the organization and delivery of care, such as structured, collaborative, multidisciplinary care together with quality improvement processes.

More empirical data are therefore needed to establish whether screening for psychiatric disorders will enhance the recognition of clinical disorder, leading to better patient outcomes.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
60 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • > 60 years without dementia,
  • Major depressive disorder,
  • Bipolar disorder,
  • Dysthymia disorder,
  • Anxiety disorder,
  • Mania/hypomania

排除标准

  • Severe post-stroke dementia or aphasia,
  • History of mania, psychiatric consultation or admission to hospital in past 3 months,
  • MMSE score <18,
  • Fully dependent at 3 or more basic activities of daily living,
  • Very high BDI score (>=30),
  • Serious suicidal risk,
  • Current psychotic symptoms,
  • Current alcohol abuse,
  • Very high GDS score (>=12) confirmed by SCID

结局指标

主要结局

Response to treatment at 6 months follow up is defined as a 50% reduction in HAMD-17 score

时间窗: 6 months

After enrolled in the study for 6 months, depressive symptoms were expected to reduce to 50% in assessment fo HAM_D 17

次要结局

  • Improvement in follow-up SF-12 scores from baseline(12 months)
  • Caregiver burden at 6 month follow-up(6 months)
  • Rates of physician and patient self-report of service utilization at 6 month follow up(6 months)
  • Patient satisfaction with care at 6 month follow up(6 months)
  • Physician feedback at 6 month follow up(6 months)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Psychological Medicine

Ng Tz Pin, MD, MFPHM, National University Hospital, Singapore

National University Hospital, Singapore

研究点 (2)

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