Impulsivity, Neural Deficits and Cocaine Addiction

Completed

• Conditions: Cocaine Dependence

• Registration Number: NCT00744601
• Lead Sponsor: University of Texas Southwestern Medical Center

Brief Summary

The purpose of this study is to assess neurocognitive and associated neural regions/circuitry disruptions relevant to impulsive relapse in cocaine-addicted subjects, and the relationship of the cognitive and neural mechanisms of impulsivity/decision-making to relapse style.

Detailed Description

This study is designed to explore putative differences in impulsive behaviors and decision making in cocaine-addicted and healthy control subjects using functional magnetic resonance imaging (fMRI), single photon emission tomography (SPECT), and neurocognitive tasks. We predict that cocaine-addicted subjects will demonstrate neurocognitive and neural alterations in measures of impulsivity and decision-making when compared to healthy controls. That is, cocaine-addicted subjects will show both decreased activation and decreased resting measures of regional cerebral blood flow (rCBF) of the brain structures associated with impulsivity and decision-making. Furthermore, neurocognitive and neural deficits associated with impulsivity and decision-making will be associated with each other and with measures indicative of an impulsive relapse and altered decision making.

Study Timeline

• Study Start: 2007-04
• Study First Submitted: 2008-06-19
• Study First Submitted QC: 2008-08-29
• Study First Posted: 2008-09-01
• Primary Completion: 2012-03
• Study Completion: 2012-09
• Status Verified: 2012-12
• Last Update Submitted: 2012-12-31
• Last Update Posted: 2013-01-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Cocaine-dependence (patient population) or no cocaine-dependence (control population).

Exclusion Criteria

• Other medical or psychiatric disorders that may effect neural functioning.
• Medications that may effect neural functioning.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determine if the brain regions involved in inhibition and decision-making are altered in cocaine-addicted subjects compared to healthy controls.	2 weeks
In cocaine-addicted subjects, determine if neural deficits during disinhibition or decision-making are related to relapse following treatment.	6 months

Secondary Outcome Measures

Name	Time	Method
Assess the predictive validity of self-report measures of impulsive relapse.	6 months

Trial Locations

Locations (1)

UT Southwestern Medical Center at Dallas, Divison on Addictions; 🇺🇸 Dallas, Texas, United States