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Gene Expression Changes of Brain Tissue in Human Temporal Lobe Epilepsy With Hippocampal Sclerosis

Conditions
Epilepsy
Hippocampal Sclerosis
Interventions
Other: RNA sequencing
First Posted Date
2021-06-08
Last Posted Date
2021-06-08
Lead Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Target Recruit Count
10
Registration Number
NCT04917939
Locations
🇨🇳

2ndAffiliated Hospital, School of Medicine, Zhejiang University, China, Hangzhou, Zhejiang, China

Restenosis in Coronary Stents And Cutaneous HEaLing

Conditions
Coronary Restenosis
Skin Scarring
Coronary Stent Occlusion
Keloid
Interventions
Diagnostic Test: Skin biopsy and blood sample for inflammation markers, RNA and proteins
First Posted Date
2021-06-07
Last Posted Date
2022-11-21
Lead Sponsor
Fundación para la Investigación Biosanitaria del Principado de Asturias
Target Recruit Count
80
Registration Number
NCT04915391
Locations
🇪🇸

Department of Cardiology, Hospital Cabueñes, Gijón, Asturias, Spain

Detection of SARS-CoV-2 RNA in Coughed Droplets From Patients With COVID-19

Not Applicable
Completed
Conditions
Covid19
Interventions
Device: PneumoniaCheck
First Posted Date
2021-06-03
Last Posted Date
2023-09-07
Lead Sponsor
Emory University
Target Recruit Count
69
Registration Number
NCT04912895
Locations
🇺🇸

Emory University Hospital Midtown, Atlanta, Georgia, United States

🇺🇸

Emory University Hospital, Atlanta, Georgia, United States

🇺🇸

Emory Children's Center, Atlanta, Georgia, United States

and more 1 locations

Second Follow-up Study of COPD Patients and Healthy Controls for Evaluation of Predictive Non-coding RNA Biomarkers

Completed
Conditions
Chronic Obstructive Pulmonary Disease
First Posted Date
2021-05-20
Last Posted Date
2024-10-11
Lead Sponsor
Fraunhofer-Institute of Toxicology and Experimental Medicine
Target Recruit Count
63
Registration Number
NCT04895124
Locations
🇩🇪

Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Lower Saxony, Germany

Safety and Tolerability Study With VY-HTT01, in Adults With Early Manifesting Huntington's Disease

Phase 1
Withdrawn
Conditions
Huntington Disease
Interventions
Genetic: Intraparenchymal rAAV1 - (mi)RNA HTT
First Posted Date
2021-05-13
Last Posted Date
2021-08-16
Lead Sponsor
Voyager Therapeutics
Registration Number
NCT04885114

Virucidal Effect of PVP-I on COVID-19 and as Well as Safety of Its Application on Nasopharynx & Oropharynx

Phase 3
Completed
Conditions
Effect of Drug
Efficacy, Self
Virus Infection, RNA
Interventions
Drug: 0.6% PVP-I Oral and nasal spray to healthy volunteer
Drug: 0.6% PVP-I oral and nasal spray to moderately ill COVID-19 positive patient
Other: Oral and nasal spray by distilled water to control group
Drug: 0.6% PVP-I Oral and nasal spray to asymptomatic to mild COVID-19 patient having multiple comorbidity
First Posted Date
2021-05-04
Last Posted Date
2022-01-20
Lead Sponsor
DR. MALA KHAN
Target Recruit Count
798
Registration Number
NCT04872686
Locations
🇧🇩

Bangladesh Reference Institute for Chemical Measurements, Dhaka, Dhanmondi, Bangladesh

🇧🇩

Kurmitola General Hospital, Dhaka, Bangladesh

🇧🇩

Kuwait-Moitree Hospital, Dhaka, Bangladesh

and more 1 locations

Multi-layer Data to Improve Diagnosis, Predict Therapy Resistance and Suggest Targeted Therapies in HGSOC

Not Applicable
Recruiting
Conditions
High Grade Ovarian Serous Adenocarcinoma
High Grade Serous Carcinoma
Interventions
Genetic: WGS and RNA sequencing
Genetic: circulating tumor DNA (ctDNA)
Diagnostic Test: FDG PET/CT imaging
First Posted Date
2021-04-15
Last Posted Date
2025-01-16
Lead Sponsor
Turku University Hospital
Target Recruit Count
200
Registration Number
NCT04846933
Locations
🇫🇮

Turku University Hospital, Turku, Finland

Study to Assess Safety, Reactogenicity and Immunogenicity of the VACCINE RNA MCTI CIMATEC HDT (HDT-301) Vaccine Against COVID-19

Phase 1
Conditions
SARS-CoV-2
Interventions
Biological: Cohort 2 RNA VACCINE MCTI CIMATEC HDT(HDT-301) vaccine
Biological: Cohort 3 VACCINE RNA MCTI CIMATEC HDT(HDT-301) vaccine
Biological: Cohort 1 VACCINE RNA MCTI CIMATEC HDT (HDT-301) vaccine
Biological: Placebo
First Posted Date
2021-04-14
Last Posted Date
2022-04-04
Lead Sponsor
SENAI CIMATEC
Target Recruit Count
90
Registration Number
NCT04844268
Locations
🇧🇷

Hospital da Bahia, Salvador, Bahia, Brazil

Role of Piwi-protein Interacting RNA, miRNA-194 and Amino Acids in Patients With Prostate Cancer

Conditions
Finding New Biomarkers That Could be Evaluated in Patients With Prostate Cancer and Clarify Their Role in Early Detection of Prostate Cancer
Interventions
Diagnostic Test: piRNAs, miRNA-194, regucalcin and plasma aminoacids levels
First Posted Date
2021-04-08
Last Posted Date
2021-04-08
Lead Sponsor
Assiut University
Target Recruit Count
120
Registration Number
NCT04835454
Locations
🇪🇬

Assiut University, Assiut, Egypt

Host RNA Profiles to Detect Infections in Young Infants

Completed
Conditions
Meningitis
Viral Infection
Urinary Tract Infections
Sepsis
Fever
Bacteremia
Bacterial Infections
Infant, Newborn, Disease
First Posted Date
2021-03-30
Last Posted Date
2022-12-28
Lead Sponsor
Rigshospitalet, Denmark
Target Recruit Count
152
Registration Number
NCT04823026
Locations
🇩🇰

Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark

🇩🇰

Department of Paediatrics and Adolescent Medicine, Herlev Hospital, Herlev, Denmark

🇩🇰

Department of Paediatrics and Adolescent Medicine, Nordsjællands Hospital - Hillerød, Hillerød, Denmark

and more 1 locations
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