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A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer

Phase 3

Active, not recruiting

Conditions: Non-Small Cell Lung Cancer

Interventions: Drug: Selpercatinib
Drug: Carboplatin
Drug: Cisplatin
Drug: Pemetrexed
Drug: Pembrolizumab

First Posted Date: 2019-12-11

Last Posted Date: 2025-04-20

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 261

Registration Number: NCT04194944

Locations: 🇫🇷
Chu Grenoble Alpes, La Tronche, Isère, France
🇮🇹
Ospedale San Gerardo-ASST Monza, Monza, Lombardia, Italy
🇮🇹
ASST Grande Ospedale Metropolitano Niguarda, Milan, Milano, Italy

and more 191 locations

TisaGenlecleucel in Elderly Patients With First-Relapsed or Primary Refractory Aggressive B-cell Non-Hodgkin Lymphoma

Phase 2

Terminated

Conditions: Non Hodgkin Lymphoma

Interventions: Drug: CTL019

First Posted Date: 2019-11-13

Last Posted Date: 2023-05-06

Lead Sponsor: University of Cologne

Target Recruit Count: 3

Registration Number: NCT04161118

Locations: 🇩🇪
University of Cologne, Cologne, Germany
🇩🇪
Universitätsklinik Essen, Klinik für Hämatologie, Essen, Germany

RICE: Radio-Immuno-Chemotherapy of Cancer of the Esophagus

Phase 2

Active, not recruiting

Conditions: Esophageal Adenocarcinoma

Interventions: Drug: Durvalumab 50 MG/ML
Drug: Tremelimumab

First Posted Date: 2019-11-12

Last Posted Date: 2024-05-09

Lead Sponsor: University of Cologne

Target Recruit Count: 56

Registration Number: NCT04159974

Locations: 🇩🇪
Klinikum der Universität München, München, Germany
🇩🇪
University of Cologne, Cologne, Germany

Breast Cancer Risk After Diagnostic Gene Sequencing

Not Applicable

Completed

Conditions: Genetic Predisposition to Disease

Interventions: Genetic: BRIDGES gene panel testing
Genetic: Breast cancer risk polygenic risk score (PRS)
Behavioral: Questionnaires

First Posted Date: 2019-10-31

Last Posted Date: 2023-01-20

Lead Sponsor: Institut Curie

Target Recruit Count: 405

Registration Number: NCT04145817

Locations: 🇩🇪
University Hospital of Cologne, Cologne, Germany
🇫🇷
Institut Curie, Paris, France

Efficacy and Safety of IgPro10 in Adults With Systemic Sclerosis (SSc)

Phase 2

Withdrawn

Conditions: Diffuse Cutaneous Systemic Sclerosis

Interventions: Biological: IgPro10
Biological: Placebo

First Posted Date: 2019-10-24

Last Posted Date: 2020-11-17

Lead Sponsor: CSL Behring

Registration Number: NCT04138485

Locations: 🇺🇸
Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States
🇺🇸
Rutgers Clinical Research Center, New Brunswick, New Jersey, United States
🇺🇸
Boston University Amyloidosis Center, Boston, Massachusetts, United States

and more 74 locations

Navigated Laparoscopic Microwave Ablation of Tumor Mimics in Pig Liver - an Ex-vivo Trial

Not Applicable

Completed

Conditions: Liver Cancer
Surgery
Navigation, Spatial

Interventions: Procedure: navigated microwave ablation
Procedure: ultrasound guided navigation

First Posted Date: 2019-09-27

Last Posted Date: 2020-02-05

Lead Sponsor: Universitätsklinikum Köln

Target Recruit Count: 4

Registration Number: NCT04106453

Locations: 🇩🇪
University of Cologne, Department of General, Visceral and Cancer Surgery, Cologne, Germany

Model for PK/PD of Antimicrobials in Blood Stream Infection: Feasibility

Conditions: Blood Stream Infections

Interventions: Other: Additional blood sampling

First Posted Date: 2019-09-10

Last Posted Date: 2020-01-21

Lead Sponsor: University of Cologne

Target Recruit Count: 120

Registration Number: NCT04083443

Locations: 🇩🇪
Klinik für Anaesthesiologie, Klinikum der Ludwig-Maximilians-Universität München, Munich, Bavaria, Germany
🇩🇪
Universitätsklinikum Leipzig AöR, Klinik für Gastroenterologie und Rheumatologie, Sektion Hepatologie, Leipzig, Saxony, Germany
🇩🇪
Klinik für Anästhesiologie und Operative Intensivmedizin Krankenhaus Köln-Merheim Klinikum der Universität Witten/ Herdecke, Cologne, North Rhine-Westphalia, Germany

and more 1 locations