Risperidone

Generic Name: Risperidone

Brand Names: Perseris, Risperdal, Rykindo, Uzedy, Okedi

Drug Type: Small Molecule

Chemical Formula: C_₂₃H_₂₇FN_₄O_₂

CAS Number: 106266-06-2

Unique Ingredient Identifier: L6UH7ZF8HC

Background: Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. Paliperidone, another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).
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Indication: Risperidone is indicated for the treatment of schizophrenia and irritability associated with autistic disorder. It is also indicated as monotherapy, or adjunctly with lithium or valproic acid, for the treatment of acute mania or mixed episodes associated with bipolar I disorder.
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Associated Conditions: Acute Mania, Irritability, Mixed manic depressive episode, Psychosis, Schizophrenia, Acute Manic episode, Agitated psychotic state

Associated Therapies: -

Clinical Trials

15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated

Phase 4

Completed

Conditions: Schizophrenia

Interventions: Drug: paliperidone palmitate
Drug: haloperidole
Drug: quetiapine
Drug: risperidone
Drug: olanzapine
Drug: aripiprazole
Drug: paliperidone
Drug: perphenazine

First Posted Date: 2010-07-07

Last Posted Date: 2015-04-24

Lead Sponsor: Janssen Scientific Affairs, LLC

Target Recruit Count: 450

Registration Number: NCT01157351

Effects of Ketamine and Risperidone on Cognition

Phase 4

Completed

Conditions: Healthy Volunteers
Schizophrenia

Interventions: Drug: saline
Drug: ketamine
Drug: placebo risperidone
Drug: risperidone

First Posted Date: 2010-06-09

Last Posted Date: 2016-11-09

Lead Sponsor: University of Manchester

Target Recruit Count: 87

Registration Number: NCT01140620

Locations: 🇬🇧
School of Psychology, University of Cardiff, Cardiff, United Kingdom
🇬🇧
Institute of Psychiatry, King's College London, London, Greater London, United Kingdom
🇬🇧
University of Manchester (Dept of Neuropyschiatry), Manchester, United Kingdom

A Long-Term, Open-Label, Study on Schizophrenia

Phase 2

Terminated

Conditions: Schizophrenia

Interventions: Drug: Olanzapine
Drug: LY2140023
Drug: Aripiprazole
Drug: Risperidone
Drug: Quetiapine

First Posted Date: 2010-05-25

Last Posted Date: 2013-01-21

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 1210

Registration Number: NCT01129674

Locations: 🇺🇦
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Vinnytsya, Ukraine

Escitalopram Treatment for BPSD in Alzheimer's Disease in Comparison to Risperidone

Phase 4

Completed

Conditions: Alzheimer's Disease
Agitation
Psychosis

Interventions: Drug: Escitalopram
Drug: Risperidone

First Posted Date: 2010-05-07

Last Posted Date: 2015-06-24

Lead Sponsor: Abarbanel Mental Health Center

Target Recruit Count: 40

Registration Number: NCT01119638

Locations: 🇮🇱
Abarbanel MHC, Bat-Yam, Israel

A Study in Schizophrenia Patients

Phase 2

Completed

Conditions: Schizophrenia

Interventions: Drug: Placebo
Drug: LY2140023
Drug: Risperidone

First Posted Date: 2010-03-15

Last Posted Date: 2012-09-25

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 880

Registration Number: NCT01086748

Locations: 🇷🇺
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Yaroslavl, Russian Federation

Is MS14 Helpful in Schizophrenia?

Phase 2

Conditions: Schizophrenia

Interventions: Drug: MS14
Drug: Risperidone

First Posted Date: 2010-03-09

Last Posted Date: 2010-03-09

Lead Sponsor: Farzan Institute

Target Recruit Count: 50

Registration Number: NCT01083381

Locations: 🇮🇷
Iran Psychiatric Training and Treatment Center, Tehran, Iran, Islamic Republic of

Risperidone Tablets, 1 mg Bioequivalence Study of Dr.Reddy's Under Fed Condition

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Risperidone

First Posted Date: 2010-02-08

Last Posted Date: 2010-02-08

Lead Sponsor: Dr. Reddy's Laboratories Limited

Target Recruit Count: 26

Registration Number: NCT01064271

Risperidone Tablets, 1 mg Bioequivalence Study of Dr.Reddy's Under Fasting Condition

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Risperidone

First Posted Date: 2010-02-08

Last Posted Date: 2010-02-08

Lead Sponsor: Dr. Reddy's Laboratories Limited

Target Recruit Count: 30

Registration Number: NCT01064232

Standard Comprehensive Intervention to Treat First-episode Schizophrenia

Not Applicable

Conditions: Schizophrenia

Interventions: Drug: risperidone
Drug: Aripiprazole
Drug: olanzapine

First Posted Date: 2010-01-27

Last Posted Date: 2010-01-27

Lead Sponsor: Peking University

Target Recruit Count: 600

Registration Number: NCT01057849

Locations: 🇨🇳
Beijing Anding Hospital, Beijing, Beijing, China
🇨🇳
Zhongnan University Xiangya Second Hospital, Changsha, Hunan, China
🇨🇳
Beijing Huilongguan Hospital, Beijing, Beijing, China

and more 3 locations

A Study to Evaluate the Safety and the Effects of Risperidone Compared With Other Atypical Antipsychotic Drugs on the Growth and Sexual Maturation in Children

Phase 4

Completed

Conditions: Schizophrenia
Bipolar Disorder
Autistic Disorder
Conduct and Other Disruptive Behavior Disorders

Interventions: Drug: Risperidone
Drug: Other atypical antipsychotic drugs

First Posted Date: 2010-01-15

Last Posted Date: 2012-11-27

Lead Sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Target Recruit Count: 244

Registration Number: NCT01050582

Drug Development Updates

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