Overview
Magnesium is classified as an alkaline earth metal and has 2 hydration shells. The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate. Common dietary sources of magnesium include nuts (cashews, peanuts, almonds), beans, bananas, apples, carrots, broccoli, and leafy greens. Magnesium is an important enzyme cofactor and is essential to several metabolic processes. Further, the mineral helps regulate blood pressure and is necessary for RNA, DNA and protein synthesis among several other functions. Despite the importance of magnesium and its availability via several food sources, an estimated 56 to 68% of adults who live in developed, western countries do not meet the recommended daily intake (RDI) of magnesium. Several factors and common behaviours reduce the availability of magnesium in the diet such as food processing and cooking vegetables (which are normally a rich source of magnesium).
Indication
Healthy levels of magnesium can be achieved through a well balanced diet, but if food sources are insufficient, magnesium supplements can be used to prevent and treat magnesium deficiencies. In medicine, various magnesium salts may be used in laxative and antacid products. For example, magnesium citrate is available over-the-counter and may be used to manage occasional constipation. Magnesium sulfate may be used on its own or with total parenteral nutrition to treat hypomagnesemia. Magnesium sulfate is also indicated to prevent seizures in pregnant women with pre-eclampsia, and to manage seizures associated with eclampsia.
Associated Conditions
- Calcium Deficiency
- Magnesium Deficiency
- Zinc Deficiency
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2025/04/01 | Phase 3 | Not yet recruiting | |||
2024/12/30 | Phase 4 | Not yet recruiting | |||
2024/12/20 | Phase 4 | Not yet recruiting | |||
2024/12/06 | Phase 2 | Not yet recruiting | |||
2024/11/26 | Phase 3 | Recruiting | BrightGene New Bio-Medical Technology(Wuxi) Co.Ltd. | ||
2024/11/22 | Phase 2 | Recruiting | |||
2024/11/12 | Phase 4 | Not yet recruiting | |||
2024/11/07 | Phase 4 | Not yet recruiting | |||
2024/10/04 | Phase 3 | Completed | Muhammad Aamir Latif | ||
2024/09/19 | Phase 2 | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Nutritional Specialties, Inc. | 83027-0036 | ORAL | 15 [hp_X] in 1 mL | 4/14/2025 | |
| Centurion Labs, LLC | 23359-105 | ORAL | 30 mg in 1 1 | 1/22/2024 | |
| Acella Pharmaceuticals, LLC | 42192-321 | ORAL | 45 mg in 1 1 | 1/5/2018 | |
| Everett Laboratories, Inc. | 0642-0092 | ORAL | 5 mg in 1 1 | 4/18/2012 | |
| Everett Laboratories, Inc. | 0642-0070 | ORAL | 20 mg in 1 1 | 9/1/2021 | |
| Pharmics, Inc. | 0813-0202 | ORAL | 100 mg in 1 1 | 9/6/2012 | |
| Exeltis USA, Inc. | 0642-0079 | ORAL | 25 mg in 1 1 | 12/31/2022 | |
| Deseret Biologicals, Inc. | 43742-1312 | ORAL | 8 [hp_X] in 1 mL | 5/27/2025 | |
| Dr. Donna Restivo DC | 62185-0062 | ORAL | 8 [hp_X] in 1 mL | 5/23/2025 | |
| Sterling-Knight Pharmaceuticals, LLC | 69336-352 | ORAL | 15 mg in 1 1 | 3/9/2020 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| Berocca Performance Original effervescent tablets | 193893 | Medicine | A | 1/17/2012 | |
| Supervite Multivitamin + Ginseng | 312495 | Medicine | A | 12/13/2018 | |
| Hydralyte Sports Orange Flavoured Effervescent Electrolyte Tablets | 346493 | Medicine | A | 10/23/2020 | |
| Hydralyte Sports Lemon Lime Flavoured Electrolyte Ice Blocks | 343445 | Medicine | A | 9/14/2020 | |
| VITAGINSENG | 81486 | Medicine | A | 1/14/2002 | |
| Berocca Hydrate effervescent tablets Raspberry Blackcurrant flavour | 458932 | Medicine | A | 8/8/2024 | |
| 1Above Reboot Citrus | 383254 | Medicine | A | 2/1/2022 | |
| Berocca energy effervescent tablets pineapple lime flavour | 462436 | Medicine | A | 9/20/2024 | |
| Vitacal | 319744 | Medicine | A | 7/4/2019 | |
| Berocca Energy Effervescent Tablets Raspberry Blackcurrant Flavour | 493008 | Medicine | A | 6/24/2025 |
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