双嘧达莫 (Aggrenox, Persantine)

概览

Dipyridamole is a phosphodiesterase inhibitor used to prevent postoperative thromboembolic events.

作用机制

Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.

适应症

For as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and also used in prevention of angina.

• Coronary Artery Disease (CAD)
• Postoperative Thromboembolism
• Stroke
• Thrombosis
• Transient Ischemic Attack