Selegiline
- Generic Name
- Selegiline
- Brand Names
- Emsam, Zelapar
- Drug Type
- Small Molecule
- Chemical Formula
- C13H17N
- CAS Number
- 14611-51-9
- Unique Ingredient Identifier
- 2K1V7GP655
Overview
A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.
Background
A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.
Indication
Monotherapy for initial treatment of Parkinson's disease, as well as an adjunct therapy in patients with a decreased response to levodopa/carbadopa. Also used for the palliative treatment of mild to moderate Alzheimer's disease and at higher doses, for the treatment of depression.
Associated Conditions
- Attention Deficit Hyperactivity Disorder (ADHD)
- Major Depressive Disorder (MDD)
- Parkinson's Disease (PD)
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2021/05/03 | Phase 4 | Completed | Second Affiliated Hospital of Soochow University | ||
2020/10/14 | Phase 2 | Recruiting | László Mangel | ||
2019/10/17 | Not Applicable | UNKNOWN | |||
2014/08/26 | Phase 4 | UNKNOWN | |||
2013/07/31 | Phase 3 | Completed | |||
2011/12/19 | Phase 2 | Completed | Midwest Biomedical Research Foundation | ||
2011/04/06 | Phase 2 | Completed | |||
2008/03/21 | Phase 4 | Completed | |||
2007/09/26 | Phase 4 | Terminated | |||
2007/09/19 | Phase 4 | Completed | Somerset Pharmaceuticals |
FDA Approved Products
Product Name | Manufacturer | Route | Strength | Approved | NDC Code |
|---|---|---|---|---|---|
ORAL | 5 mg in 1 1 | 2022/04/01 | 71205-888 | ||
ORAL | 5 mg in 1 1 | 2018/11/28 | 50090-2918 | ||
ORAL | 5 mg in 1 1 | 2023/12/27 | 60429-176 | ||
A2A Integrated Pharmaceuticals | ORAL | 5 mg in 1 1 | 2024/02/28 | 73141-006 | |
ORAL | 5 mg in 1 1 | 2011/07/03 | 68151-2649 | ||
ORAL | 5 mg in 1 1 | 2023/03/03 | 10135-737 | ||
ORAL | 5 mg in 1 1 | 2021/12/15 | 72319-006 | ||
TRANSDERMAL | 12 mg in 24 h | 2020/05/15 | 49502-902 | ||
TRANSDERMAL | 6 mg in 24 h | 2020/05/15 | 49502-900 | ||
TRANSDERMAL | 9 mg in 24 h | 2020/05/15 | 49502-901 |
EMA Approved Products
Medicine Name | EMA Number | Auth. Holder | Country | Drug Type | Status | Issued | Opinion | Revision |
|---|
No EMA products found
No EMA products found for this drug
HSA Approved Products
Product Name | Manufacturer | Dosage Form | Strength | Approved | Approval No. |
|---|---|---|---|---|---|
TABLET | 5 mg | 1996/04/30 | SIN08681P |
NMPA Approved Products
Product Name | Approval No. | Manufacturer | Dosage Form | Trade Name | Strength | Type | Status | Date | Import |
|---|---|---|---|---|---|---|---|---|---|
国药准字H20040632 | N/A | N/A | 5mg | Chemical Drug | Approved | 2010/08/20 | Domestic | ||
国药准字H20113448 | 片剂 | N/A | 5mg | Chemical Drug | Approved | 2022/02/24 | Domestic | ||
国药准字HJ20160342 | 片剂 | 咪多吡 | 5mg | Chemical Drug | Approved | 2020/11/17 | Import | ||
国药准字H20234721 | 片剂 | N/A | 5mg | Chemical Drug | Approved | 2024/03/06 | Domestic | ||
国药准字H20133055 | 片剂 | N/A | 5mg | Chemical Drug | Approved | 2023/02/01 | Domestic | ||
国药准字H20090217 | 胶囊剂 | 辅安 | 5mg | Chemical Drug | Approved | 2023/09/27 | Domestic |
PPB Approved Products
Product Name | Registration Code | Company | Category | Sale Type | Reg. Date |
|---|
No PPB products found
No PPB products found for this drug
TGA Approved Products
Product Name | ARTG ID | Sponsor | Status | Reg. Date | Ingredient |
|---|---|---|---|---|---|
47465 | Active | 1994/01/18 | selegiline hydrochloride |