Belladonna

Overview

Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family Solanaceae. Its roots, leaves and fruits contain Hyoscyamine, Scopolamine, and mostly, Atropine. These alkaloids are naturally-occurring muscarinic antagonists. Atropine is a non-selective muscarinic antagonist that is mainly used as an adjunct for anaesthesia. The name "belladonna" originates from the Italian words "beautiful woman" and the historical use of herb eye-drops by women to dilate the pupils of the eyes for aesthetic purposes. Belladonna is a poisonous plant and belladonna intoxication from accidental ingestion may result in a severe anticholinergic syndrome, which is associated with both central and peripheral manifestations .

Indication

No therapeutic indications.

Associated Conditions

Bloating
Heartburn
Menopausal Symptoms
Poisoning of the Intestine
Poisoning of the Stomach
Reflux Acid
Belching
Gastrointestinal spasms

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
B&O for TLH Post-operative Pain and Nausea	2018/09/05	NCT03657407	Phase 4	Completed	Anna Reinert
The Use of Belladonna and Opium Suppository in the Treatment of Postoperative Stent Pain	2017/11/06	NCT03332056	Phase 4	Completed	University of Washington
Timing of B and O Suppositories to Help Relieve Post-operative Bladder Spasms	2016/08/12	NCT02865395	Phase 4	Terminated	Campbell Grant
Reduction of Bladder Injection Pain With Belladonna Opiate Suppository	2015/11/09	NCT02600715	Phase 4	Completed	Edgar LeClaire, MD
Assessing Maternal Post-partum Pain With Suppositories	2011/01/07	NCT01271855	Phase 4	Completed	Loyola University
Postoperative Belladonna and Morphine Suppositories in Vaginal Surgery	2010/06/25	NCT01150474	Phase 4	Completed	Kristina A. Butler
Effects of Perioperative B&O Suppositories on Post-op Pain and Morphine Use After Laparoscopic Prostatectomy	2009/03/18	NCT00863928	Not Applicable	Completed	Benaroya Research Institute

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Immu-n Waker	Newton Laboratories, Inc.	55714-2596	ORAL	15 [hp_X] in 1 mL	5/21/2025
Sciatic Nerve Formula	King Bio Inc.	57955-6031	ORAL	10 [hp_X] in 59 mL	5/23/2025
Immu-n Waker	Newton Laboratories, Inc.	55714-4862	ORAL	15 [hp_X] in 1 mL	5/21/2025
Incontinence	Newton Laboratories, Inc.	55714-4748	ORAL	15 [hp_X] in 1 mL	8/20/2025
Bestmade Natural Products - Mullein Ear Drops	Bestmade Natural Products	82969-6015	AURICULAR (OTIC)	30 [hp_C] in 30 [hp_C]	5/27/2025
Headache Relief	King Bio Inc.	57955-2830	ORAL	10 [hp_X] in 59 mL	5/20/2025
Belladonna 30X	Laboratoire Schmidt-Nagel Inc.	73296-004	SUBLINGUAL, ORAL	30 [hp_X] in 1 g	5/20/2025
Inflammation	Newton Laboratories, Inc.	55714-2467	ORAL	15 [hp_X] in 1 mL	8/27/2025
Bite, Bump and Rash Relief	Peaceful Mountain, Inc.	43846-0079	TOPICAL	12 [hp_X] in 1 g	5/21/2025
Belladonna and Opium	Padagis US LLC	0574-7045	RECTAL	16.2 mg in 1 1	8/8/2018

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
TRI-MAG-GEL B TAB	N/A	NATIONAL PHARMACEUTICAL INDUSTRIES CO.	N/A	N/A	7/23/1981

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
Traumeel Cream	376439	bWellness Pty Ltd	Medicine	A	10/15/2021
BRAUER DRY COUGH	124132	Brauer Natural Medicine Pty Ltd	Medicine	A	12/10/2005
Baby & Child Teething Gel	347981	Brauer Natural Medicine Pty Ltd	Medicine	A	11/11/2020
Mucosa compositum N	124349	bWellness Pty Ltd	Medicine	A	12/19/2005
TRAUMEEL S	82622	bWellness Pty Ltd	Medicine	A	5/1/2002

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
MEDIPLEX 610 - LIQ	mediherb inc.	02117002	Liquid - Oral	14 X / ML	12/19/1996
APIS BELLADONNA	Wala-Heilmittel GmbH	02232697	Liquid , Pellet - Oral	3 D	3/30/1998
PREMNIX HP	terra botanica products ltd.	02233359	Liquid - Oral	30 X	5/25/1998
HOMEO-FORM R - GRANULES	homeocan inc.	02151413	Tablet - Oral	9 X	12/31/1995
SINIX	terra botanica products ltd.	02233367	Liquid - Oral	30 X	5/25/1998
HEPTOTHESAN B57-LIQ	professional health products	02157799	Liquid - Oral	4 D / ML	12/31/1996
WIGRAINE TAB	organon canada ltd ltee	00489220	Tablet - Oral	.1 MG / TAB	12/31/1980
DROSETUX	dolisos laboratoires s.a.	02242696	Syrup - Oral	3 CH / 250 ML	10/6/2000
BELLADONNA-HOMACCORD	Biologische Heilmittel Heel Gmbh	02231981	Drops - Oral	3 D	8/28/1997
BR-NIX SPRAY	terra botanica products ltd.	02233303	Liquid - Topical	12 X	5/25/1998

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

AI-Powered Research

Premium Access