Overview
Bendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Indication
Bendamustine is indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen.
Associated Conditions
- Chronic Lymphocytic Leukemia
- Follicular Non-Hodgkin's Lymphoma Refractory
- Refractory Hodgkin Lymphoma
- Refractory Mantle Cell Lymphoma
- Waldenström's Macroglobulinemia (WM)
- Recurrent multiple myeloma
- Refractory indolent B cell non-hodgkin lymphoma
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2010/08/11 | Phase 2 | Terminated | |||
2010/08/09 | Phase 1 | Terminated | Sherif Farag, MB, BS | ||
2010/07/27 | Phase 1 | Withdrawn | |||
2010/07/23 | Phase 2 | Completed | Austrian Forum Against Cancer | ||
2010/07/19 | Phase 1 | Completed | |||
2010/06/29 | Phase 1 | Completed | |||
2010/06/10 | Phase 1 | Completed | |||
2010/05/07 | Phase 2 | Completed | |||
2010/04/26 | Phase 2 | Completed | |||
2010/04/23 | Phase 2 | Completed |
FDA Drug Approvals
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UK EMC Drug Information
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