Carbetocin

Generic Name: Carbetocin

Brand Names: Duratocin

Drug Type: Small Molecule

Chemical Formula: C_₄₅H_₆₉N_₁₁O_₁₂S

CAS Number: 37025-55-1

Unique Ingredient Identifier: 88TWF8015Y

Background: Carbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is an analogue of oxytocin, and its action is similar to that of oxytocin -- it causes contraction of the uterus.

Indication: Used to control postpartum hemorrhage and bleeding after giving birth.

Associated Conditions: Postpartum Haemorrhage (PPH), Uterine Atony

Associated Therapies: -

Clinical Trials

Early Usage of Bakri Ballon in Managing Postpartum Hemorrhage

Not Applicable

Completed

Conditions: Postpartum Hemorrhage

Interventions: Device: Bakri Balloon
Drug: Oxytocin
Drug: Hemabate
Drug: Duratocin
Procedure: Uterine Massage
Procedure: B-lynch Suture
Procedure: Uterine Artery Embolization using sponges
Procedure: Cervical cerclage
Procedure: Hysterectomy
Drug: Blood Product

First Posted Date: 2016-08-10

Last Posted Date: 2016-12-16

Lead Sponsor: Dongyu Wang

Target Recruit Count: 472

Registration Number: NCT02861482

Locations: 🇨🇳
Obstetrics and Gynechology Department of the 1st affiliated hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

Misoprostol+Oxytocin vs. Carbetocin in CS

Phase 2

Completed

Conditions: Cesarean Section

Interventions: Drug: Misoprostol
Drug: Carbetocin
Drug: Placebo
Drug: Oxytocin

First Posted Date: 2016-06-01

Last Posted Date: 2020-07-08

Lead Sponsor: Ain Shams University

Target Recruit Count: 600

Registration Number: NCT02786992

Locations: 🇪🇬
Ain Shams University Maternity Hospital, Cairo, Egypt

Effect of the Uterotonic Carbetocin on Acute Post Cesarean-Section Pain

Phase 4

Conditions: Cesarean Delivery

Interventions: Drug: Carbetocin

First Posted Date: 2015-12-30

Last Posted Date: 2018-05-04

Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Target Recruit Count: 78

Registration Number: NCT02642263

Locations: 🇨🇭
Dep. of Anesthesiology and Pain Medicine, Bern University Hospital, Bern, Switzerland

Cardiovascular Effects of Carbetocin Given During Elective Cesarean

Phase 4

Completed

Conditions: Effect of Carbetocin on Cardiovascular System
Pregnancy

Interventions: Drug: carbetocin

First Posted Date: 2015-12-22

Last Posted Date: 2016-11-17

Lead Sponsor: University of British Columbia

Target Recruit Count: 57

Registration Number: NCT02636816

Locations: 🇨🇦
BC Women's Hospital, Vancouver, British Columbia, Canada

The Clinical Carbetocin Myocardium Trial

Phase 4

Completed

Conditions: Pregnancy

Interventions: Drug: Carbetocin
Drug: Oxytocin

First Posted Date: 2015-08-19

Last Posted Date: 2021-06-14

Lead Sponsor: Oslo University Hospital

Target Recruit Count: 40

Registration Number: NCT02528136

Locations: 🇳🇴
Oslo University Hospital, Division of Emergencies and Critical Care, Oslo, Norway

Carbetocin Versus Ergometrine in the Management of Atonic Post Partum Haemorrhage (PPH) in Women Delivered Vaginally

Phase 3

Conditions: Post Partum Hemorrhage

Interventions: Drug: Carbetocin
Drug: Ergometrine

First Posted Date: 2015-04-08

Last Posted Date: 2016-07-06

Lead Sponsor: Cairo University

Target Recruit Count: 200

Registration Number: NCT02410759

Locations: 🇪🇬
BeniSuef University hospitals, BeniSuef, Egypt
🇪🇬
Cairo university hospitals, Cairo, Egypt

Carbetocin Versus Oxytocin in Caesarean Section for the Control of Postpartum Haemorrhage

Early Phase 1

Conditions: Postpartum Haemorrhage

Interventions: Drug: Carbetocin

First Posted Date: 2015-03-24

Last Posted Date: 2015-03-24

Lead Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Target Recruit Count: 100

Registration Number: NCT02396303

Locations: 🇧🇩
BSMMU, Dhaka, Bangladesh

Carbetocin and Oxytocin in Elective Caesarean Section With High Risk of Postpartum Hemorrhage

Phase 4

Completed

Conditions: Postpartum Hemorrhage

Interventions: Drug: Carbetocin
Drug: Oxytocin

First Posted Date: 2015-03-18

Last Posted Date: 2017-01-25

Lead Sponsor: Ghamra Military Hospital

Target Recruit Count: 264

Registration Number: NCT02391636

Locations: 🇪🇬
Ghamra Military Hospital, Cairo, Egypt

Carbetocin Versus Oxytocin in the Management of Atonic Post Partum Haemorrhage (PPH) in Women Delivered Vaginally: A Randomised Controlled Trial

Phase 3

Completed

Conditions: Obstetrics

Interventions: Drug: Carbetocin
Drug: Oxytocin

First Posted Date: 2014-12-01

Last Posted Date: 2016-01-27

Lead Sponsor: Cairo University

Target Recruit Count: 100

Registration Number: NCT02304055

Locations: 🇪🇬
BeniSuef University hospitals, BeniSuef, Egypt
🇪🇬
Cairo University Hospitals, Cairo, Egypt

Carbetocin Versus Oxytocin in the Prevention of Post Partum Haemorrhage (PPH) in Women Delivered Vaginally With at Least 2 Risk Factors for Atonic PPH: A Randomised Controlled Trial

Phase 3

Completed

Conditions: Delivery

Interventions: Drug: Oxytocin
Drug: Carbetocin

First Posted Date: 2014-12-01

Last Posted Date: 2015-07-02

Lead Sponsor: Cairo University

Target Recruit Count: 200

Registration Number: NCT02304042

Locations: 🇪🇬
BeniSuef University hospitals, BeniSuef, Egypt
🇪🇬
Cairo University Hospitals, Cairo, Egypt

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