未知生产厂商
Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products. It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit. It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%. The name dimethicone has a lot of nomenclature inconsistencies as it is used to refer to common names, generic names, trade names or even for the listing of mixtures. It is reported that the term dimethicone includes the notation of polydimethylsiloxane and trimethylsiloxy-terminated fluids between 20-30,000 cSt (viscosity).
Dimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products. It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit. It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%. The name dimethicone has a lot of nomenclature inconsistencies as it is used to refer to common names, generic names, trade names or even for the listing of mixtures. It is reported that the term dimethicone includes the notation of polydimethylsiloxane and trimethylsiloxy-terminated fluids between 20-30,000 cSt (viscosity).
Dimethicone, as well as all silicone derivatives, is considered as an occlusive and emollient agent. All occlusive agents act physically blocking transepidermal water loss by the formation of a hydrophobic film on the skin surface and within the superficial interstitium between corneocytes. Simethicone is often combined in drug products with petrolatum, which makes it greasy. The emollient characteristic of dimethicone is performed by filling the space between skin flakes which smooths the skin. For its use as an anti-flatulent agent, dimethicone 410 acts as an antifoaming agent and it works by reducing the surface tension of gas bubbles. This causes the combination of the bubbles to form larger bubbles in the stomach which can pass easily by means of belching. The use of dimethicone 410 in anti-lice medication has not been fully elucidated but it seems to be related to the disruption of the water balance mechanism in the lice which leads to the rupture of the gut.
Dimethicone is approved as a transdermal drug delivery system. Dimethicone 410 is part of the simethicone element in Dow Corning Q7-2242 LVA which is an antifoam. Some OTC's containing dimethicone are used to relieve the discomfort of infant gas caused by air swallowing or certain formulas or food, to prevent and help rash, to protect and relieve chapped or cracked skin and as an anti-lice agent.
共 6 项相关疾病
