Ifosfamide

Generic Name: Ifosfamide

Brand Names: Ifex

Drug Type: Small Molecule

Chemical Formula: C_₇H_₁₅Cl_₂N_₂O_₂P

CAS Number: 3778-73-2

Unique Ingredient Identifier: UM20QQM95Y

Background: Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.

Indication: Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indi...

Associated Conditions: Bladder Cancer, Cervical Cancer, Ewing's Sarcoma, Head And Neck Cancer, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma (NHL), Osteosarcoma, Ovarian Cancer, Pancreatic Cancer, Small Cell Lung Cancer (SCLC), Soft Tissue Sarcoma, Testicular Germ Cell Cancer, Thymoma

Associated Therapies: -

Clinical Trials

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer

Phase 2

Completed

Conditions: Brain and Central Nervous System Tumors
Extragonadal Germ Cell Tumor
Ovarian Cancer
Teratoma
Testicular Germ Cell Tumor

Interventions: Biological: filgrastim
Drug: carboplatin
Drug: etoposide
Drug: ifosfamide
Drug: paclitaxel
Procedure: autologous bone marrow transplantation
Procedure: bone marrow ablation with stem cell support

First Posted Date: 2003-01-27

Last Posted Date: 2017-02-23

Lead Sponsor: City of Hope Medical Center

Target Recruit Count: 48

Registration Number: NCT00002931

Locations: 🇺🇸
City of Hope Comprehensive Cancer Center, Duarte, California, United States

Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia

First Posted Date: 2003-01-27

Last Posted Date: 2014-02-27

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 220

Registration Number: NCT00022737

Locations: 🇺🇸
Children's Oncology Group, Arcadia, California, United States

Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma

Phase 3

Completed

Conditions: Sarcoma

First Posted Date: 2003-01-27

Last Posted Date: 2013-09-17

Lead Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Target Recruit Count: 340

Registration Number: NCT00003052

Locations: 🇩🇪
Robert Roessle Comprehensive Cancer Center at University of Berlin - Charite Campus Buch, Berlin, Germany
🇩🇪
Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany
🇩🇪
Universitaetsklinikum Essen, Essen, Germany

and more 1 locations

Chemotherapy and Peripheral Stem Cell Transplant With or Without Monoclonal Antibody Therapy in Treating Patients With Non-Hodgkin's Lymphoma

Phase 3

Completed

Conditions: Lymphoma

First Posted Date: 2003-01-27

Last Posted Date: 2013-08-12

Lead Sponsor: Commissie Voor Klinisch Toegepast Onderzoek

Target Recruit Count: 340

Registration Number: NCT00012051

Locations: 🇳🇱
Academisch Medisch Centrum at University of Amsterdam, Amsterdam, Netherlands
🇧🇪
U.Z. Gasthuisberg, Leuven, Belgium
🇳🇱
HagaZiekenhuis - Locatie Leyenburg, 's-Gravenhage, Netherlands

and more 14 locations

Combination Chemotherapy With or Without Radiation Therapy and Peripheral Stem Cell Transplant in Treating Children With Hodgkin's Lymphoma

Phase 2

Conditions: Lymphoma

First Posted Date: 2003-01-27

Last Posted Date: 2013-08-07

Lead Sponsor: Children's Cancer and Leukaemia Group

Target Recruit Count: 260

Registration Number: NCT00025064

Locations: 🇬🇧
Birmingham Children's Hospital, Birmingham, England, United Kingdom
🇬🇧
Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, United Kingdom
🇬🇧
Leeds Cancer Centre at St. James's University Hospital, Leeds, England, United Kingdom

and more 17 locations

Combination Chemotherapy With or Without Whole-Body Hyperthermia in Treating Patients With Recurrent Ovarian Epithelial, Fallopian Tube, or Peritoneal Cancer

Phase 2

Conditions: Fallopian Tube Cancer
Ovarian Cancer
Primary Peritoneal Cavity Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2013-08-07

Lead Sponsor: Ludwig-Maximilians - University of Munich

Target Recruit Count: 241

Registration Number: NCT00045461

Locations: 🇩🇪
Charite University Hospital - Campus Virchow Klinikum, Berlin, Germany
🇩🇪
Universitaets - Kinderklinik - Luebeck, Luebeck, Germany
🇩🇪
Kreiskrankenhaus Trostberg, Trostberg, Germany

and more 4 locations

Docetaxel and Ifosfamide in Treating Women With Metastatic Breast Cancer

Phase 2

Conditions: Breast Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2013-08-07

Lead Sponsor: Grupo Oncologico Cooperativo del Sur

Target Recruit Count: 42

Registration Number: NCT00026078

Locations: 🇦🇷
C.R I O., Mar del Plata, Argentina
🇦🇷
Centro Oncologico Tres Arroyos, Tres Arroyos, Argentina
🇦🇷
Unidad Oncologica Del Neuquen, Neuquen, Argentina

and more 5 locations

Chemotherapy and Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma

Phase 2

Completed

Conditions: Neuroblastoma

First Posted Date: 2003-01-27

Last Posted Date: 2013-08-02

Lead Sponsor: German Society for Pediatric Oncology and Hematology GPOH gGmbH

Registration Number: NCT00017225

Locations: 🇩🇪
Carl - Thiem - Klinkum Cottbus, Cottbus, Germany
🇩🇪
Klinikum Lippe - Detmold, Detmold, Germany
🇩🇪
Praxis am Evangelischen Krankenhaus Bethanien, Iserlohn, Germany

and more 85 locations

Radiation Therapy Compared With Combination Chemotherapy in Treating Patients With Cancer of the Uterus

Phase 3

Completed

Conditions: Sarcoma

First Posted Date: 2003-01-27

Last Posted Date: 2016-02-11

Lead Sponsor: Gynecologic Oncology Group

Target Recruit Count: 216

Registration Number: NCT00002546

Locations: 🇺🇸
UPMC Cancer Center at Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States
🇺🇸
Women's Cancer Center - Los Gatos, Los Gatos, California, United States
🇺🇸
Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center, Orange, California, United States

and more 61 locations

Chemotherapy Followed by Peripheral Stem Cell or Bone Marrow Transplant Compared With Chemotherapy Alone in Treating Patients With Small Cell Lung Cancer

Phase 3

Conditions: Lung Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2013-09-17

Lead Sponsor: EBMT Solid Tumors Working Party

Target Recruit Count: 430

Registration Number: NCT00011921

Locations: 🇨🇭
Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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