Overview
Sulforaphane is under investigation for the treatment of Autism Spectrum Disorder. It is a naturally occurring isothiocyanate found in high concentration in a variety of broccoli.
Indication
No indication information available.
Associated Conditions
No associated conditions information available.
Research Report
Sulforaphane (DB12422): A Comprehensive Monograph on its Chemistry, Pharmacology, and Therapeutic Potential
Executive Summary
Sulforaphane (SFN) is a naturally occurring isothiocyanate phytochemical derived from cruciferous vegetables, most notably broccoli and broccoli sprouts. As an investigational small molecule, SFN has garnered significant scientific interest due to its pleiotropic biological activities and potential therapeutic applications across a spectrum of chronic diseases. This report provides a comprehensive analysis of SFN, synthesizing current knowledge on its chemistry, pharmacology, clinical evidence, safety profile, and regulatory landscape.
The therapeutic potential of SFN is rooted in two primary, complementary mechanisms of action. Its most well-characterized activity is as a potent indirect antioxidant through the activation of the Nuclear factor erythroid 2-related factor 2 (Nrf2) transcriptional pathway. By modulating the Nrf2-Keap1 signaling axis, SFN upregulates a vast array of cytoprotective genes, including phase II detoxification and antioxidant enzymes, thereby fortifying cellular defenses against oxidative stress and inflammation. Concurrently, SFN functions as a histone deacetylase (HDAC) inhibitor, an epigenetic mechanism that can restore the expression of silenced tumor suppressor genes and modulate protein stability, which is particularly relevant to its anticancer effects.
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2025/06/27 | Not Applicable | Not yet recruiting | |||
2023/04/04 | Phase 2 | Active, not recruiting | |||
2022/12/16 | Phase 2 | Recruiting | |||
2022/06/07 | Phase 1 | Recruiting | |||
2022/02/04 | Phase 4 | UNKNOWN | Sunshine Specialty Health Care | ||
2021/12/10 | Phase 1 | Completed | |||
2021/10/19 | Phase 2 | Recruiting | Central South University | ||
2020/08/21 | Phase 2 | Completed | Central South University | ||
2020/02/05 | Phase 2 | UNKNOWN | Xiangya Hospital of Central South University | ||
2020/01/29 | Phase 2 | UNKNOWN | Central South University |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| No Health Canada approvals found for this drug. | |||||
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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