Cidofovir
- Generic Name
- Cidofovir
- Brand Names
- Vistide
- Drug Type
- Small Molecule
- Chemical Formula
- C8H14N3O6P
- CAS Number
- 113852-37-2
- Unique Ingredient Identifier
- 768M1V522C
- Background
Cidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis. It was manufactured by Gilead and initially approved by the FDA in 1996, but has since been discontinued.
- Indication
用于治疗免疫功能缺陷患者不能耐受更昔洛韦和膦甲酸钠治疗或治疗无效的巨细胞病毒感染。
- Associated Conditions
- Cytomegalovirus Retinitis, Herpes Simplex Virus, Monkeypox, Variola Major (Smallpox)
- Associated Therapies
- -
Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2011-02-23
- Target Recruit Count
- 300
- Registration Number
- NCT00000894
- Locations
- 🇺🇸
Cornell Univ Med Ctr, New York, New York, United States
🇺🇸Julio Arroyo, West Columbia, South Carolina, United States
🇺🇸New York Hosp / Cornell Med Ctr, New York, New York, United States
Cidofovir as a Treatment for Herpes Simplex in Patients With AIDS
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gilead Sciences
- Registration Number
- NCT00002181
- Locations
- 🇺🇸
HIV Primary Care & Consult, Santa Rosa, California, United States
🇺🇸AIDS Healthcare Foundation Labs, Los Angeles, California, United States
🇺🇸Dr Susan M Diamond, Dallas, Texas, United States
A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease
- Conditions
A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-10-29
- Target Recruit Count
- 24
- Registration Number
- NCT00000945
- Locations
- 🇺🇸
Rush Presbyterian - Saint Luke's Med Ctr, Chicago, Illinois, United States
🇺🇸San Francisco AIDS Clinic / San Francisco Gen Hosp, San Francisco, California, United States
🇺🇸Univ of Alabama at Birmingham, Birmingham, Alabama, United States
Phase II Randomized Study of Cidofovir for Peripheral Cytomegalovirus Retinitis
- Conditions
- First Posted Date
- 2000-02-25
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 90
- Registration Number
- NCT00004794
Studies of the Ocular Complications of AIDS (SOCA)--HPMPC Peripheral CMV Retinitis Trial (HPCRT)
- First Posted Date
- 1999-09-24
- Last Posted Date
- 2015-11-17
- Lead Sponsor
- Johns Hopkins Bloomberg School of Public Health
- Target Recruit Count
- 64
- Registration Number
- NCT00000142
Drug Development Updates
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