Glucosamine

Overview

Osteoarthritis (OA) is a progressive and degenerative joint disease marked by loss of cartilage, bone changes, and synovial membrane inflammation. Treatment with chondroprotective drugs, such as glucosamine sulfate may offer additional benefits to nonsteroidal anti-inflammatory drugs treating the painful symptoms of OA. Glucosamine is commonly used over the counter as a treatment for arthritic joint pain, although its acceptance as a medical therapy varies due to contradictory and findings with unclear clinical significance during clinical trials. It is currently not approved as a prescription product by the FDA, but is widely available over the counter.

Indication

Glucosamine is generally used over the counter in the symptomatic treatment of osteoarthritis and joint pain, frequently combined with chondroitin sulfate and/or ibuprofen.

Associated Conditions

Back pain
Joint Pain
Osteoarthritis (OA)
Osteoarthritis of the Knee
Articular inflammation

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Efficacy of Topical Glucosamine Versus Corticosteroid in Oral Lichen Planus	2025/08/11	NCT07114016	Not Applicable	Completed	Future University in Egypt
Glucosamine Sulphate Versus Ginger in Non-Surgical Periodontal Therapy	2024/01/11	NCT06200415	Phase 2	Completed	Ain Shams University
Prescription-grade Crystalline Glucosamine Sulfate Therapy in Erosive Hand Osteoarthritis	2022/02/14	NCT05237596	N/A	Completed	University of Siena
Clinical Study to Evaluate the Effect of Different Doses of UC-II® Supplementation on the Range of Motion & Joint Discomfort in Healthy Subjects	2022/01/28	NCT05212259	Not Applicable	Recruiting	Vedic Lifesciences Pvt. Ltd.
A Parallel-group Active Comparator, Double-blind, Multicenter, Randomized, Double-blind, Phase III Clinical Study	2019/05/03	NCT03936192	Phase 3	Withdrawn	Eurofarma Laboratorios S.A.
Crystalline Glucosamine Sulfate Therapy in Hand Osteoarthritis	2019/04/11	NCT03911570	N/A	Completed	University of Siena
Transdermal Delivery of Glucosamine to the Synovial Fluid of Male and Female With Knee Osteoarthritis	2018/11/16	NCT03743896	Phase 4	Completed	Lynk Biotechnologies Pte Ltd
Therapeutic Approaches to Malnutrition Enteropathy	2018/10/23	NCT03716115	Phase 2	Completed	Queen Mary University of London
Individual Differences in Glucosamine Sulfate Exposure Levels	2017/06/28	NCT03201276	N/A	UNKNOWN	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus	2016/08/08	NCT02858297	Phase 4	Completed	Ain Shams University

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Remaxazon External Patch	Home Aide Diagnostics, Inc.	69379-285	TOPICAL	5 g in 100 g	3/9/2015
Gout Relief 3310-S	Bispit Canada Ltd.	85631-003	ORAL	130 mg in 1.3 g	8/2/2025

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
GLUCOSAMINE POWDER FOR ORAL SOLUTION 1.5G/SACHET	N/A	STAR MEDICAL AND GENERAL SUPPLIES (PTY) LTD	N/A	N/A	3/23/2009

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
Quality Health Australia Daily Glucosamine Sulfate 1500mg	235126	Pharmacare Laboratories Pty Ltd	Medicine	A	3/17/2015
Glucosamine HCL 1500mg TAB	169608	Star Combo Australia Pty Ltd	Medicine	A	3/5/2010
Glucosamine Powder Sachet	157319	Carlmark International Pty Ltd	Medicine	A	11/27/2008
JointBiotics Glucosamine 1500mg and Chondroitin 100mg	302975	Olivebiotics Pty Ltd	Medicine	A	5/14/2018
YHL 3 IN 1 FORMULA JOINT MOBILITY	354030	Universal Pharmaceuticals Pty Ltd	Medicine	A	2/2/2021
Glucosamine Premium Repair	315815	McPherson's Consumer Products Pty Ltd	Medicine	A	3/27/2019
Austar Joint Care	444208	Austar Pharma Pty Ltd	Medicine	A	3/22/2024
JoinTQ	384091	Axpo Pty Ltd	Medicine	A	2/16/2022
BioSource Glucosamine HCl 1500 mg	331183	Soul Pattinson Manufacturing Pty Ltd	Medicine	A	3/16/2020
Thompson's Glucosamine & Chondroitin with Boron	406330	Homart Wellness Aust Pty Ltd	Medicine	A	3/17/2023

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
No Health Canada approvals found for this drug.

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
DUARTRON 625 mg CAPSULAS DURAS	Laboratorio Reig Jofre, S.A.	75658	CÁPSULA DURA	Medicamento Sujeto A Prescripción Médica	Commercialized

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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