Overview
Chlorobutanol, or chlorbutol, is an alcohol-based preservative with no surfactant activity . It also elicits sedative-hypnotic and weak local anesthetic actions in addition to antibacterial and antifungal properties. Similar in nature to chloral hydrate, it is formed by the simple nucleophilic addition of chloroform and acetone. As a long-term stabilizer of multi-ingredient preparations, chlorobutanol is normally used at a concentration of 0.5%. At this concentration, it also conserves its antimicrobial activity. Due to the long terminal half-life of 37 days, the use of chlorobutanol as a sedative is limited because of the considerable accumulation which will occur following multiple dosing . Chlorobutanol is a common detergent preservative in eye drops and other ophthalmic therapeutic formulations .
Indication
No approved therapeutic indications on its own.
Associated Conditions
- Acute Sinusitis
- Allergy to Tree Pollen
- Infective otitis externa
- Rhinitis
- Acute Rhinitis
- Acute rhino-sinusitis
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|
No clinical trials found
No clinical trials found for this drug
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| BALMINIL NASAL OINTMENT | rougier pharma division of ratiopharm inc | 02135639 | Ointment - Nasal | 2 MG / G | 12/31/1995 |
| NEUTRALITE LIQ | canadian custom packaging company | 00313467 | Liquid - Topical | 1.41875 Kg / 576 L | 12/31/1964 |
| OUTGRO LIQUID | whitehall-robins inc. | 01934015 | Liquid - Topical | 4.7 % | 12/31/1993 |
| ORALGAR DPS | produits marc-o (1987) inc., division of technilab inc. | 00400602 | Drops - Otic | 490 MG / 30 ML | 12/15/1989 |
| DSO DRESSING | 00232661 | Liquid - Dental | 38.3 G / 100 ML | 12/31/1963 | |
| DRY SOCKET PASTE | sultan healthcare | 00479225 | Paste - Dental | 1.5 % | 12/31/1985 |
| AURISAN DPS | lab nadeau ltée, division of technilab inc. | 00417009 | Drops - Otic | 15 MG / ML | 12/31/1977 |
| RHINO-VACCIN | rougier pharma division of ratiopharm inc | 00167983 | Ointment - Nasal | 2 MG / 1 G | 12/31/1951 |
| LARYNSOL LOZ | herbes universelles inc. | 00444758 | Lozenge - Oral | .6 MG / LOZ | 12/31/1979 |
| CERUMOL | 00221570 | Drops - Otic | 5 % | 12/31/1971 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
Help Us Improve
Your feedback helps us provide better drug information and insights.