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9MW-3011

Generic Name
9MW-3011

Overview

No overview information available.

Background

No background information available.

Indication

No indication information available.

Associated Conditions

No associated conditions information available.

Research Report

Published: May 12, 2025

Comprehensive Report on 9MW-3011: A Novel TMPRSS6-Targeting Monoclonal Antibody for Iron Homeostasis Disorders

I. Introduction

9MW-3011 (also known by its US R&D code MWTX-003 and as DISC-3405 by Disc Medicine) is an investigational monoclonal antibody engineered to target Transmembrane Serine Protease 6 (TMPRSS6).[1] Developed by Mabwell (Shanghai) Bioscience at its San Diego Innovation and R&D Center, 9MW-3011 represents a novel therapeutic approach aimed at regulating iron homeostasis in the human body.[1] The primary mechanism involves the upregulation of hepcidin, a key hormone controlling iron absorption and mobilization.[1] Mabwell has entered into a significant licensing agreement with Disc Medicine, Inc. for the development and commercialization of 9MW-3011 in major territories outside of Greater China and Southeast Asia.[1]

This report provides a comprehensive analysis of 9MW-3011, detailing its mechanism of action, preclinical evidence, the current status of its clinical development program across various indications, its regulatory designations, the commercial and intellectual property landscape, and its therapeutic potential in addressing unmet medical needs in disorders characterized by iron dysregulation.

Table 1: Key Characteristics of 9MW-3011

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FDA Drug Approvals

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NMPA Drug Approvals

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PPB Drug Approvals

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