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Timolol

Generic Name
Timolol
Brand Names
Azarga, Betimol, Combigan, Cosopt, Duotrav, Istalol, Timoptic, Xalacom
Drug Type
Small Molecule
Chemical Formula
C13H24N4O3S
CAS Number
26839-75-8
Unique Ingredient Identifier
5JKY92S7BR
Background

Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective agent for the management of conditions such as open-angle glaucoma and hypertension.

Indication

Ophthalmic timolol is indicated for the treatment of increased intraocular pressure in patients with ocular hypertension or open-angle glaucoma. The oral form of this drug is used to treat high blood pressure. In certain cases, timolol is used in the prevention of migraine headaches.

Associated Conditions
Increased Intra Ocular Pressure (IOP), Migraine, Ocular Hypertension, Open Angle Glaucoma (OAG)
Associated Therapies
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springermedizin.de
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Long-Term Safety and Efficacy Evaluation of Travoprost Intracameral Implant Based on ...

Eligibility criteria for OAG/OHT study eyes include C/D ratio ≤ 0.8, visual field mean deviation ≥ −12 dB, BCVA 20/80 or better, and specific IOP requirements. Exclusions involve prior glaucoma surgeries, ocular conditions affecting measurements, and systemic diseases. Procedures include informed consent, ophthalmic assessments, and randomization to FE/SE implants or sham. Follow-up visits assess IOP, visual acuity, and adverse events. Statistical analysis aims to confirm non-inferiority of implant effects on IOP reduction.
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