Timolol

Generic Name: Timolol

Brand Names: Azarga, Betimol, Combigan, Cosopt, Duotrav, Istalol, Timoptic, Xalacom

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₂₄N_₄O_₃S

CAS Number: 26839-75-8

Unique Ingredient Identifier: 5JKY92S7BR

Background: Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective agent for the management of conditions such as open-angle glaucoma and hypertension.

Indication: Ophthalmic timolol is indicated for the treatment of increased intraocular pressure in patients with ocular hypertension or open-angle glaucoma. The oral form of this drug is used to treat high blood pressure. In certain cases, timolol is used in the prevention of migraine headaches.

Associated Conditions: Increased Intra Ocular Pressure (IOP), Migraine, Ocular Hypertension, Open Angle Glaucoma (OAG)

Clinical Trials

Travoprost Intracameral Implant Shows Sustained IOP Reduction in Glaucoma Patients

9 months ago

• A travoprost intracameral implant demonstrated non-inferiority in reducing intraocular pressure (IOP) compared to timolol eye drops over 12 months in glaucoma patients. • The implant provided a sustained IOP reduction, with a favorable safety profile observed throughout the study period. • The study suggests the travoprost implant as a potential alternative to topical medications for managing open-angle glaucoma or ocular hypertension. • The implant is placed nasally into the trabecular meshwork and sclera, offering a novel approach to IOP control.

Drug Development Updates

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