Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain
Associated Therapies
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Toradol v. Celecoxib for Postoperative Pain

Phase 2
Completed
Conditions
Interventions
First Posted Date
2017-11-06
Last Posted Date
2023-12-07
Lead Sponsor
Michael Ulm, MD
Target Recruit Count
170
Registration Number
NCT03331315
Locations
🇺🇸

Methodist Hospital System, Memphis, Tennessee, United States

Analysis for NSAID VS Corticosteroid Shoulder Injection in Diabetic Patients

First Posted Date
2017-10-24
Last Posted Date
2019-02-15
Lead Sponsor
Milton S. Hershey Medical Center
Registration Number
NCT03319784
Locations
🇺🇸

Penn State College of Medicine, Hershey, Pennsylvania, United States

Ketorolac on Posterior Thoracolumbar Spinal Fusions

Phase 4
Recruiting
Conditions
Interventions
First Posted Date
2017-09-12
Last Posted Date
2023-04-20
Lead Sponsor
Ascension South East Michigan
Target Recruit Count
600
Registration Number
NCT03278691
Locations
🇺🇸

Providence-Providence Park, Southfield, Southfield, Michigan, United States

Ketamine v. Ketorolac for Management of Generalized Tension Type Headache

First Posted Date
2017-07-18
Last Posted Date
2018-07-06
Lead Sponsor
The Brooklyn Hospital Center
Target Recruit Count
60
Registration Number
NCT03221569
Locations
🇺🇸

The Brooklyn Hospital Center, Brooklyn, New York, United States

Comparative Study Between the Effect of Diclofanic and Ketorolac in Post Tonsillectomy Pain Management

Phase 2
Completed
Conditions
Interventions
First Posted Date
2017-06-07
Last Posted Date
2020-07-14
Lead Sponsor
Assiut University
Target Recruit Count
100
Registration Number
NCT03178539
Locations
🇪🇬

Assiut university hospital, Assiut, Asyut Governorate, Egypt

Lidocaine vs Ketorolac for Management of Renal Colic in the Emergency Department

Phase 4
Conditions
Interventions
First Posted Date
2017-05-02
Last Posted Date
2018-07-11
Lead Sponsor
The Brooklyn Hospital Center
Target Recruit Count
60
Registration Number
NCT03137498
Locations
🇺🇸

The Brooklyn Hospital Center, Brooklyn, New York, United States

Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement

First Posted Date
2017-04-18
Last Posted Date
2022-10-27
Lead Sponsor
Rush University Medical Center
Registration Number
NCT03119038
Locations
🇺🇸

Rush University Medical Center, Chicago, Illinois, United States

Toradol to Reduce Ureteroscopic Symptoms Trial

First Posted Date
2017-04-12
Last Posted Date
2021-11-02
Lead Sponsor
Yale University
Target Recruit Count
94
Registration Number
NCT03111381
Locations
🇺🇸

Yale Medial Center, New Haven, Connecticut, United States

Status Migrainosus - Differentiating Between Responders and Non-responders

First Posted Date
2017-02-28
Last Posted Date
2018-08-31
Lead Sponsor
Hartford HealthCare
Target Recruit Count
50
Registration Number
NCT03066544
Locations
🇺🇸

Hartford HealthCare Headache Center, Wethersfield, Connecticut, United States

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