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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

Platelet Function and Safety After IV and Oral Diclofenac, IV Ketorolac and Oral Aspirin in Adult Volunteers

First Posted Date
2007-10-24
Last Posted Date
2008-07-16
Lead Sponsor
Javelin Pharmaceuticals
Target Recruit Count
30
Registration Number
NCT00548678
Locations
🇺🇸

Comprehensive Phase One, Miramar, Florida, United States

A Study of Ketorolac for the Treatment of Inflammation and Pain Associated With Cataract Surgery

Phase 3
Completed
Conditions
Cataract Extraction
Pain
Inflammation
Interventions
First Posted Date
2007-09-03
Last Posted Date
2009-10-01
Lead Sponsor
Allergan
Target Recruit Count
248
Registration Number
NCT00524264

A Study of Ketorolac for the Treatment of Inflammation and Pain Associated With Cataract Surgery

Phase 3
Completed
Conditions
Cataract Extraction
Interventions
First Posted Date
2007-08-27
Last Posted Date
2009-10-01
Lead Sponsor
Allergan
Target Recruit Count
263
Registration Number
NCT00521456

Bromfenac 0.09% vs Ketorolac 0.4% for Cyclosporine Induction Phase

Phase 4
Completed
Conditions
Dry Eye Disease
Ocular Comfort
Interventions
First Posted Date
2007-08-23
Last Posted Date
2009-02-19
Lead Sponsor
Florida Eye Microsurgical Institute
Target Recruit Count
42
Registration Number
NCT00520260
Locations
🇺🇸

Florida Eye Microsurgical Institute, Boynton Beach, Florida, United States

Efficacy and Safety of IV Diclofenac (DIV075V)for Pain After Elective Orthopedic Surgery

Phase 3
Completed
Conditions
Postoperative Pain
Interventions
Drug: IV Diclofenac
Drug: Placebo
First Posted Date
2007-07-25
Last Posted Date
2021-10-29
Lead Sponsor
Pfizer
Target Recruit Count
277
Registration Number
NCT00507026
Locations
🇺🇸

American Institute of Healthcare and Fitness, Raleigh, North Carolina, United States

🇺🇸

University Orthopedics Center, State College, Pennsylvania, United States

🇺🇸

Arizona Research Center, Phoenix, Arizona, United States

and more 5 locations

An Analgesia Protocol for Acute Renal Colic in the Emergency Department

Not Applicable
Completed
Conditions
Kidney Stone
First Posted Date
2007-07-19
Last Posted Date
2007-10-18
Lead Sponsor
Dartmouth-Hitchcock Medical Center
Target Recruit Count
45
Registration Number
NCT00504283
Locations
🇺🇸

DHMC, Lebanon, New Hampshire, United States

Anti-inflammatory Therapy Following Selective Laser Trabeculoplasty

Not Applicable
Completed
Conditions
Pseudoexfoliation Glaucoma
Primary Open Angle Glaucoma
Interventions
First Posted Date
2007-06-12
Last Posted Date
2015-09-23
Lead Sponsor
Queen's University
Target Recruit Count
120
Registration Number
NCT00485108
Locations
🇨🇦

Queen's University, Kingston, Ontario, Canada

Efficacy and Safety of Intranasal Ketorolac for the Acute Treatment of Migraine

Phase 2
Completed
Conditions
Migraine
Interventions
First Posted Date
2007-06-07
Last Posted Date
2016-09-30
Lead Sponsor
Egalet Ltd
Target Recruit Count
173
Registration Number
NCT00483717
Locations
🇩🇪

Volker Pfaffenrath, Munich, Bavaria, Germany

Comparing Acular LS and Pred Forte in Reducing Post-selective Laser Trabeculoplasty Anterior Chamber Flare and Cells

Not Applicable
Terminated
Conditions
Open Angle Glaucoma
Interventions
First Posted Date
2007-05-24
Last Posted Date
2016-10-07
Lead Sponsor
University of Colorado, Denver
Target Recruit Count
31
Registration Number
NCT00478036
Locations
🇺🇸

University of Colorado Eye Center, Aurora, Colorado, United States

Efficacy of Topical Ketorolac Versus Placebo for Improving Visual Outcomes Following Multifocal IOL Implantation

Phase 4
Completed
Conditions
Macula Thickening
First Posted Date
2007-02-09
Last Posted Date
2007-09-10
Lead Sponsor
Innovative Medical
Registration Number
NCT00433225
Locations
🇺🇸

Ophthalmic Consultants of Long Island, Rockville Centre, New York, United States

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