Ketorolac

Generic Name: Ketorolac

Brand Names: Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik

Drug Type: Small Molecule

Chemical Formula: C_₁₅H_₁₃NO_₃

CAS Number: 74103-06-3

Unique Ingredient Identifier: YZI5105V0L

Background: Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.
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Indication: Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid...

Associated Conditions: Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

Associated Therapies: -

Clinical Trials

Multimodal Pain Management After Robotic-Assisted Total Laparoscopic Hysterectomy

Phase 3

Completed

Conditions: Pain, Postoperative

Interventions: Drug: Gabapentin
Drug: Hydromorphone
Drug: Acetaminophen
Drug: Celecoxib
Drug: Ketorolac
Procedure: Paracervical block with ropivacaine
Procedure: Local anesthetic injection with ropivacaine at abdominal laparoscopic port sites
Drug: Oxycodone

First Posted Date: 2020-06-11

Last Posted Date: 2023-08-01

Lead Sponsor: State University of New York at Buffalo

Target Recruit Count: 68

Registration Number: NCT04429022

Locations: 🇺🇸
Millard Fillmore Suburban Hospital, Williamsville, New York, United States

Effects of Pre-emptive Scalp Infiltration With Low-dose Ketorolac and Ropivacaine for Postoperative Pain

Phase 4

Conditions: Pain
Supratentorial Brain Tumor

Interventions: Drug: Ropivacaine
Drug: Ketorolac
Drug: Epinephrine

First Posted Date: 2020-05-08

Last Posted Date: 2020-09-09

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 40

Registration Number: NCT04380298

Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache

Phase 1

Withdrawn

Conditions: Chronic Migraine
Cluster Headache
Trigeminal Neuralgia

Interventions: Drug: Ketorolac
Drug: Dexamethasone

First Posted Date: 2020-04-20

Last Posted Date: 2020-08-04

Lead Sponsor: Weill Medical College of Cornell University

Registration Number: NCT04353505

Locations: 🇺🇸
Weill Cornell Medicine, New York, New York, United States

Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid

Phase 2

Recruiting

Conditions: Acute Pancreatitis

Interventions: Drug: Opioid
Drug: Ketorolac

First Posted Date: 2020-03-02

Last Posted Date: 2024-02-14

Lead Sponsor: Boston Children's Hospital

Target Recruit Count: 50

Registration Number: NCT04291599

Locations: 🇺🇸
Boston Children's Hospital, Boston, Massachusetts, United States

Ketorolac in Acute Pancreatitis

Phase 4

Conditions: Acute Pancreatitis

Interventions: Drug: Ketorolac

First Posted Date: 2020-02-24

Last Posted Date: 2020-12-08

Lead Sponsor: University of Cincinnati

Target Recruit Count: 60

Registration Number: NCT04282200

Locations: 🇺🇸
University of Cincinnati Medical Center, Cincinnati, Ohio, United States

Multimodal Pain Study in Free Flap Patients

Phase 4

Completed

Conditions: Analgesia
Head and Neck Cancer

Interventions: Drug: Tylenol
Drug: Oxycodone
Drug: Morphine
Drug: Gabapentin
Drug: toradol
Drug: Bupivacaine

First Posted Date: 2020-01-29

Last Posted Date: 2023-08-18

Lead Sponsor: University of Kansas Medical Center

Target Recruit Count: 30

Registration Number: NCT04246697

Locations: 🇺🇸
University of Kansas Medical Center, Kansas City, Kansas, United States

Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery

Phase 3

Completed

Conditions: ACL Injury
Postoperative Pain

Interventions: Drug: Oxycodone-Acetaminophen
Drug: Ketorolac

First Posted Date: 2020-01-29

Last Posted Date: 2021-12-21

Lead Sponsor: University Hospitals Cleveland Medical Center

Target Recruit Count: 49

Registration Number: NCT04246554

Locations: 🇺🇸
UH Cleveland Medical Center, Cleveland, Ohio, United States

Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery

Phase 3

Completed

Conditions: Opioid Use
Postoperative Complications
Pain, Postoperative
Ketorolac Adverse Reaction
Meniscus Tear, Tibial

Interventions: Drug: Oxycodone-Acetaminophen
Drug: Ketorolac

First Posted Date: 2020-01-29

Last Posted Date: 2022-03-03

Lead Sponsor: University Hospitals Cleveland Medical Center

Target Recruit Count: 48

Registration Number: NCT04246541

Locations: 🇺🇸
UH Cleveland Medical Center, Cleveland, Ohio, United States

Effects of Pre-emptive Scalp Infiltration With Ketorolac and Ropivacaine for Post-craniotomy Pain

Phase 4

Conditions: Pain
Supratentorial Brain Tumor

Interventions: Drug: Ketorolac
Drug: Ropivacaine
Drug: Epinephrine

First Posted Date: 2019-10-28

Last Posted Date: 2020-01-22

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 100

Registration Number: NCT04141319

Ibuprofen Versus Ketorolac by Mouth in the Treatment of Acute Pain From Osteoarticular Trauma

Phase 3

Completed

Conditions: Acute Pain Due to Trauma

Interventions: Drug: Ketorolac
Drug: Ibuprofen

First Posted Date: 2019-10-21

Last Posted Date: 2022-01-06

Lead Sponsor: IRCCS Burlo Garofolo

Target Recruit Count: 212

Registration Number: NCT04133623

Locations: 🇮🇹
Azienda Ospedaliera Santa Maria degli Angeli, Pordenone, Italy
🇮🇹
Institute for Maternal and Child Health - IRCCS Burlo Garofolo-, Trieste, Italy
🇮🇹
Ospedale Santa Maria della Misericordia, Udine, Italy

Drug Development Updates

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