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Testosterone cypionate

Generic Name
Testosterone cypionate
Brand Names
Depo-testosterone
Drug Type
Small Molecule
Chemical Formula
C27H40O3
CAS Number
58-20-8
Unique Ingredient Identifier
M0XW1UBI14
Background

Testosterone cypionate is a synthetic derivative of testosterone in the form of an oil-soluble 17 (beta)-cyclopentylpropionate ester. Its benefit compared to other testosterone derivatives is the slow rate of release after injection and longer half-life. It was developed by the company Pharmacia and Upjohn and FDA approved on July 25, 1979.

Indication

Testosterone cypionate is used in males that present conditions derived from a deficiency or absence of endogenous testosterone. These conditions are 1) primary hypogonadism, defined as the testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome or orchidectomy; and 2) hypogonadotropic hypogonadism characterized by idiopathic gonadotropin, LHRH deficiency or pituitary-hypothalamic injury from tumors, trauma or radiation.

Associated Conditions
Hypergonadotropic Hypogonadism, Hypogonadotrophic Hypogonadism
Associated Therapies
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Bipolar Androgen Therapy: Rationale, Candidate Patients, and Latest Evidence for mCRPC Patients

Bipolar androgen therapy (BAT) cycles between high and low testosterone levels to treat metastatic castrate-resistant prostate cancer (mCRPC), showing safety and efficacy. It sensitizes cancer cells to androgen receptor inhibition, improves quality of life, and is cost-effective. Clinical trials like TRANSFORMER and RESTORE explore BAT's role, with ongoing studies investigating combinations with other therapies for mCRPC treatment.
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